CAS 51828-97-8|MTOB
| Common Name | MTOB | ||
|---|---|---|---|
| CAS Number | 51828-97-8 | Molecular Weight | 170.16200 |
| Density | / | Boiling Point | / |
| Molecular Formula | C5H7NaO3S | Melting Point | >300ºC(lit.) |
| MSDS | ChineseUSA | Flash Point | / |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | sodium,4-methylsulfanyl-2-oxobutanoate |
|---|---|
| Synonym | More Synonyms |
MTOB BiologicalActivity
| Description | MTOB sodium is a potent C-terminal binding protein (CtBP) inhibitor. MTOB sodium attenuates repetitive head injury-elicited neurologic dysfunction and neuroinflammation via inhibition of the transactivation activity of CtBP1 and CtBP2. MTOB sodium antagonizes the transcriptional regulatory activity of CtBP1 and CtBP2 by eviction from their target promoters in breast cancer cell lines[1][2]. |
|---|---|
| Related Catalog | Research Areas >>CancerSignaling Pathways >>Others >>OthersResearch Areas >>Inflammation/ImmunologyResearch Areas >>Neurological Disease |
| Target | CtBP[1] |
| In Vitro | MTOB sodium (10 mM) causes significant derepression (P<0.05) of 40% of CtBP target genes (including FGF9, CTNNB1, CEBPB, et al.) in MCF-7 and 46% in MBA-MD-231; increases the pro-epithelial E-cadherin/Vimentin ratio while reducing the pro-mesenchymal CD44/CD24 ratio, with a more significant trend (P<0.05) in MCF-7[2]. |
| In Vivo | MTOB sodium (860 mg/kg; IP, at 1 h and 18 h after the first injury) effectively suppresses the increases duration of righting reflex, and significantly decreased neurological severity score (NSS) scores[1]. Animal Model: C57BL/6 mice (traumatic brain injury)[1] Dosage: 860 mg/kg Administration: IP, at 1 h and 18 h after the first injury Result: Effectively suppressed the increased duration of righting reflex, and significantly decreased NSS scores. |
| References | [1]. Li H, et al. C-terminal binding proteins 1 and 2 in traumatic brain injury-induced inflammation and their inhibition as an approach for anti-inflammatory treatment. Int J Biol Sci. 2020 Feb 4;16(7):1107-1120. [2]. Di LJ, et al. Genome-wide profiles of CtBP link metabolism with genome stability and epithelial reprogramming in breast cancer. Nat Commun. 2013;4:1449. |
Chemical & Physical Properties
| Melting Point | >300ºC(lit.) |
|---|---|
| Molecular Formula | C5H7NaO3S |
| Molecular Weight | 170.16200 |
| Exact Mass | 170.00100 |
| PSA | 82.50000 |
| InChIKey | IFSCKRWNXKWTLR-UHFFFAOYSA-M |
| SMILES | CSCCC(=O)C(=O)[O-].[Na+] |
| Storage condition | 2-8°C |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi |
| Risk Phrases | 36/37/38 |
| Safety Phrases | 26-36 |
| RIDADR | UN 3335 |
| HS Code | 2930909090 |
Customs
| HS Code | 2930909090 |
|---|---|
| Summary | 2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
Articles29
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Synonyms
| KMBA |
| MFCD00010511 |
| sodium 4-methylsulfanyl-2-oxo-butyrate |
| UNII-2EZY36W75U |
| Sodium 4-(methylthio)-2-oxobutanoate |
| sodium 4-methylthio-2-oxobutyrate |
| Fema No. 3881 |
| 4-Methylthio-2-oxobutanoic acid sodium salt |
