CAS 916603-07-1|CZC8004

Introduction：Basic information about CAS 916603-07-1|CZC8004, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. CZC8004 BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Customs
6. Synonyms

Common Name	CZC8004
CAS Number	916603-07-1	Molecular Weight	309.341
Density	1.3±0.1 g/cm3	Boiling Point	514.1±60.0 °C at 760 mmHg
Molecular Formula	C₁₇H₁₆FN₅	Melting Point	/
MSDS	/	Flash Point	264.7±32.9 °C

Names

Name	N2-(4-(Aminomethyl)phenyl)-5-fluoro-N4-phenylpyrimidine-2,4-diamine
Synonym	More Synonyms

CZC8004 BiologicalActivity

Description	CZC-8004 is a pan-kinase inhibitor and binds a range of tyrosine kinases, including ABL kinase.
Related Catalog	Signaling Pathways >>Protein Tyrosine Kinase/RTK >>Bcr-AblResearch Areas >>Cancer
References	[1]. CZC-8004 is a pan-kinase inhibitor, with low micromolar IC₅₀ values for tyrosine kinase. [2]. Bantscheff M, et al. Quantitative chemical proteomics reveals mechanisms of action of clinical ABL kinase inhibitors. Nat Biotechnol. 2007 Sep;25(9):1035-44.

Description

CZC-8004 is a pan-kinase inhibitor and binds a range of tyrosine kinases, including ABL kinase.

Related Catalog

Signaling Pathways >>Protein Tyrosine Kinase/RTK >>Bcr-AblResearch Areas >>Cancer

References

[1]. CZC-8004 is a pan-kinase inhibitor, with low micromolar IC₅₀ values for tyrosine kinase.

[2]. Bantscheff M, et al. Quantitative chemical proteomics reveals mechanisms of action of clinical ABL kinase inhibitors. Nat Biotechnol. 2007 Sep;25(9):1035-44.

Chemical & Physical Properties

Density	1.3±0.1 g/cm3
Boiling Point	514.1±60.0 °C at 760 mmHg
Molecular Formula	C₁₇H₁₆FN₅
Molecular Weight	309.341
Flash Point	264.7±32.9 °C
Exact Mass	309.138977
PSA	75.86000
LogP	2.27
Vapour Pressure	0.0±1.3 mmHg at 25°C
Index of Refraction	1.699
InChIKey	UKOHFWNBTUJMMN-UHFFFAOYSA-N
SMILES	NCc1ccc(Nc2ncc(F)c(Nc3ccccc3)n2)cc1

Safety Information

HS Code	2921499090

Customs

HS Code	2921499090
Summary	2921499090 other aromatic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Synonyms

N-[4-(Aminomethyl)phenyl]-5-fluoro-N-phenyl-2,4-pyrimidinediamine

CZC8004

2-N-[4-(aminomethyl)phenyl]-5-fluoro-4-N-phenylpyrimidine-2,4-diamine

2,4-Pyrimidinediamine, N-[4-(aminomethyl)phenyl]-5-fluoro-N-phenyl-

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