Introduction：Basic information about CAS 916210-98-5|(2-Chloropyridin-4-yl)methanamine hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | (2-Chloropyridin-4-yl)methanamine hydrochloride |
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| CAS Number | 916210-98-5 | Molecular Weight | 179.047 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C6H8Cl2N2 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | (2-Chloropyridin-4-yl)methanamine hydrochloride |
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| Synonym | More Synonyms |
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BiologicalActivity
| Description | LOXL2-IN-1 hydrochloride is a selective LOXL2 inhibitor with an IC50 of 126 nM. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Inflammation/ImmunologyResearch Areas >>Cardiovascular Disease |
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| Target | IC50: 126 nM (LOXL2)[1] |
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| In Vitro | LOXL2-IN-1 is shown to be selective for LOXL2 over LOX and three other amine oxidases (MAO-A, MAO-B and SSAO). In the human whole blood LOXL2 assay, LOXL2-IN-1 has an IC50 of 1.45 µM compared to 126 nM in the absence of blood proteins. LOXL2-IN-1 shows a 31-fold selectivity for LOXL2+BSA (IC50=190 nM) over LOX+BSA (IC50=5.91 µM). Against a panel of non-LTQ-containing AO enzymes (MAO-A, MAO-B and SSAO), LOXL2-IN-1 is found to be inactive at 30 µM. LOXL2-IN-1 is profiled for the inhibition of three different CYP enzymes (CYPs 3A4, 2C9 and 2D6) and in each case the IC50 is more than 30 µM[1]. |
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| References | [1]. Hutchinson JH, et al. Small Molecule Lysyl Oxidase-like 2 (LOXL2) Inhibitors: The Identification of an Inhibitor Selective for LOXL2 over LOX. ACS Med Chem Lett. 2017 Mar 1;8(4):423-427. |
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Chemical & Physical Properties
| Molecular Formula | C6H8Cl2N2 |
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| Molecular Weight | 179.047 |
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| Exact Mass | 178.006454 |
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| PSA | 38.91000 |
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| LogP | 2.69600 |
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Safety Information
Customs
| HS Code | 2933399090 |
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| Summary | 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| (2-chloropyridin-4-yl)methanamine,hydrochloride |
| 1-(2-Chloro-4-pyridinyl)methanamine hydrochloride (1:1) |
| 4-Pyridinemethanamine, 2-chloro-, hydrochloride (1:1) |
