CAS 120926-46-7|Isoliquiritin apioside
Introduction：Basic information about CAS 120926-46-7|Isoliquiritin apioside, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Isoliquiritin apioside | ||
|---|---|---|---|
| CAS Number | 120926-46-7 | Molecular Weight | 550.509 |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 901.0±65.0 °C at 760 mmHg |
| Molecular Formula | C26H30O13 | Melting Point | / |
| MSDS | / | Flash Point | 301.9±27.8 °C |
Names
| Name | (E)-3-[4-[(2S,3R,4S,5S,6R)-3-[(2S,3R,4R)-3,4-dihydroxy-4-(hydroxymethyl)oxolan-2-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]-1-(2,4-dihydroxyphenyl)prop-2-en-1-one |
|---|---|
| Synonym | More Synonyms |
Isoliquiritin apioside BiologicalActivity
| Description | Isoliquiritin apioside, a component isolated from Glycyrrhizae radix rhizome, significantly decreases PMA-induced increases in MMP9 activities and suppresses PMA-induced activation of MAPK and NF-κB. Isoliquiritin apioside auppresseses invasiveness and angiogenesis of cancer cells and endothelial cells[1]. |
|---|---|
| Related Catalog | Research Areas >>CancerSignaling Pathways >>MAPK/ERK Pathway >>p38 MAPKSignaling Pathways >>Metabolic Enzyme/Protease >>MMP |
| Target | MMP9 NF-κB p38 MAPK |
| In Vitro | Isoliquiritin apioside efficiently suppresses the PMA-induced gelatinolytic MMP-9 activity in HT1080 cells. Isoliquiritin apiosidealso decreases the PMA-induced increase in MMP-9 production in HT1080 cells.Isoliquiritin apioside possesses anti-metastatic and anti-angiogenic abilities in malignant cancer cells and endothelial cells (ECs), with no cytotoxicity[1]. |
| References | [1]. Kim A1, et al. Isoliquiritin Apioside Suppresses in vitro Invasiveness and Angiogenesis of Cancer Cells and Endothelial Cells.Front Pharmacol. 2018 Dec 10;9:1455. |
Chemical & Physical Properties
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 901.0±65.0 °C at 760 mmHg |
| Molecular Formula | C26H30O13 |
| Molecular Weight | 550.509 |
| Flash Point | 301.9±27.8 °C |
| Exact Mass | 550.168640 |
| PSA | 215.83000 |
| LogP | 1.96 |
| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
| Index of Refraction | 1.709 |
| InChIKey | VMMVZVPAYFZNBM-KVFWHIKKSA-N |
| SMILES | O=C(C=Cc1ccc(OC2OC(CO)C(O)C(O)C2OC2OCC(O)(CO)C2O)cc1)c1ccc(O)cc1O |
Synonyms
| 2-Propen-1-one, 1-(2,4-dihydroxyphenyl)-3-[4-[[2-O-[(2S,3R,4R)-tetrahydro-3,4-dihydroxy-4-(hydroxymethyl)-2-furanyl]-β-D-glucopyranosyl]oxy]phenyl]-, (2E)- |
| 4-[(1E)-3-(2,4-Dihydroxyphenyl)-3-oxo-1-propen-1-yl]phenyl 2-O-[(2S,3R,4R)-3,4-dihydroxy-4-(hydroxymethyl)tetrahydro-2-furanyl]-β-D-glucopyranoside |
| Neolicuroside |
