CAS 123122-55-4|Candoxatril

Introduction：Basic information about CAS 123122-55-4|Candoxatril, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Candoxatril BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	Candoxatril
CAS Number	123122-55-4	Molecular Weight	515.63800
Density	1.21g/cm3	Boiling Point	718.4ºC at 760mmHg
Molecular Formula	C₂₉H₄₁NO₇	Melting Point	/
MSDS	/	Flash Point	388.3ºC

Names

Name	candoxatril
Synonym	More Synonyms

Candoxatril BiologicalActivity

Description	Candoxatril is a neutral endopeptidase (NEP) inhibitor.
Related Catalog	Signaling Pathways >>Metabolic Enzyme/Protease >>NeprilysinResearch Areas >>Metabolic Disease
Target	NEP[1].
In Vivo	While the NEP inhibitors have no significant effect on body weight, food and water intake, mean blood pressure or creatinine levels, they do increase cGMP levels in the urine and affected hematopoiesis in an anti-inflammatory way. Moreover, a-SMA deposition in the kidney cortex is inversely correlated with cGMP elevation suggesting a NEP dependent antifibroti effect. High quality mRNA profiles are obtained with at least 8 independent samples per treatment group. The data confirms the cGMP dependent anti-fibrotic action of Sol-1 and further supports the potential therapeutic actions of this neutral endopeptidase inhibitor[2].
Animal Admin	Mice[2] Mice (n=10 per group) subjected to UUO are treated for 1 week with either Solvent, SOL-1 (NEP-/ECE-inhibitor two doses), Candoxatril (reference NEP inhibitor) or losartan (angiotensin AT1-receptor antagonist) and compared to sham operated animals[2].
References	[1]. Bevan EG, et al. Candoxatril, a neutral endopeptidase inhibitor: efficacy and tolerability in essential hypertension. J Hypertens. 1992 Jul;10(7):607-13. [2]. M Aleksinskaya, et al. Neutral endopeptidase inhibitors SOL-1 and candoxatril counteract kidney fibrosis by reducing myofibroblast formation in mouse UUO model. Bmc Pharmacology & Toxicology , 2013 , 14 (1) :1-2.

Chemical & Physical Properties

Density	1.21g/cm3
Boiling Point	718.4ºC at 760mmHg
Molecular Formula	C₂₉H₄₁NO₇
Molecular Weight	515.63800
Flash Point	388.3ºC
Exact Mass	515.28800
PSA	114.65000
LogP	4.91030
InChIKey	ZTWZVMIYIIVABD-RZMWZJFBSA-N
SMILES	COCCOCC(CC1(C(=O)NC2CCC(C(=O)O)CC2)CCCC1)C(=O)Oc1ccc2c(c1)CCC2

Safety Information

Hazard Codes	Xi

Synonyms

4-[[1-[(2S)-3-(2,3-dihydro-1H-inden-5-yloxy)-2-(2-methoxyethoxymethyl)-3-oxopropyl]cyclopentanecarbonyl]amino]cyclohexane-1-carboxylic acid

Candoxatril

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