CAS 857891-82-8|Azido-PEG8-amine

Introduction：Basic information about CAS 857891-82-8|Azido-PEG8-amine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Azido-PEG8-amine BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Articles1
6. Synonyms

Common Name	Azido-PEG8-amine
CAS Number	857891-82-8	Molecular Weight	438.51600
Density	/	Boiling Point	/
Molecular Formula	C₁₈H₃₈N₄O₈	Melting Point	/
MSDS	ChineseUSA	Flash Point	/
Symbol	GHS07	Signal Word	Warning

Names

Name	2-[2-[2-[2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanamine
Synonym	More Synonyms

Azido-PEG8-amine BiologicalActivity

Description	Azido-PEG8-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >>CancerSignaling Pathways >>PROTAC >>PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

Molecular Formula	C₁₈H₃₈N₄O₈
Molecular Weight	438.51600
Exact Mass	438.26900
PSA	149.61000
LogP	0.54126
InChIKey	ZSFGTBJYBWJOLZ-UHFFFAOYSA-N
SMILES	[N-]=[N+]=NCCOCCOCCOCCOCCOCCOCCOCCOCCN
Storage condition	2-8°C

Safety Information

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	Xi: Irritant;
Risk Phrases	36/37/38
Safety Phrases	26
RIDADR	NONH for all modes of transport
WGK Germany	3

Articles1

Spatioselective Modification of Bicompartmental Polymer Particles and Fibers via Huisgen 1, 3‐Dipolar Cycloaddition Bhaskar S, et al.

Macromol. Rapid Commun. 29(20) , 1655-1660, (2008)

Synonyms

Azido-PEG-amine (n=8)

O-(2-Aminoethyl)-O'-(2-azidoethyl)heptaethylene glycol

O-(2-Aminoethyl)-O inverted exclamation marka-(2-azidoethyl)heptaethylene glycol

26-Azido-3,6,9,12,15,18,21,24-octaoxahexacosan-1-amine

Recommended......