Introduction：Basic information about CAS 57096-02-3|4'-Hydroxywogonin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 4'-Hydroxywogonin |
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| CAS Number | 57096-02-3 | Molecular Weight | 300.263 |
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| Density | 1.5±0.1 g/cm3 | Boiling Point | 578.1±50.0 °C at 760 mmHg |
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| Molecular Formula | C16H12O6 | Melting Point | / |
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| MSDS | / | Flash Point | 220.9±23.6 °C |
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Names
| Name | 5,7-dihydroxy-2-(4-hydroxyphenyl)-8-methoxychromen-4-one |
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| Synonym | More Synonyms |
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4'-Hydroxywogonin BiologicalActivity
| Description | 4′-Hydroxywogonin (8-Methoxyapigenin), a flavonoid, could be isolated from a variety of plants including Scutellaria barbata and Verbena littoralis. 4′-Hydroxywogonin has anti-inflammatory activity via TAK1/IKK/NF-κB, MAPKs and PI3/AKT signaling pathways. 4′-Hydroxywogonin inhibits angiogenesis by disrupting PI3K/AKT signaling. 4′-Hydroxywogonin inhibits cell proliferation and induces apoptosis[1][2][3]. |
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| Related Catalog | Signaling Pathways >>Apoptosis >>Bcl-2 FamilySignaling Pathways >>NF-κB >>IKKSignaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>CancerResearch Areas >>Cardiovascular DiseaseSignaling Pathways >>Immunology/Inflammation >>Interleukin RelatedSignaling Pathways >>PI3K/Akt/mTOR >>PI3KSignaling Pathways >>Apoptosis >>CaspaseSignaling Pathways >>MAPK/ERK Pathway >>p38 MAPKSignaling Pathways >>PI3K/Akt/mTOR >>AktResearch Areas >>Inflammation/Immunology |
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| In Vitro | 4′-Hydroxywogonin (8-Methoxyapigenin; 0.5-15 μM; 0-24 h) has low cytotoxicity and inhibits NO and PGE2 production in LPS-stimulated RAW 264.7 macrophages by suppression of iNOS and COX-2 expression[1]. 4′-Hydroxywogonin (0.5-15 μM; 1 and 12 h) suppresses LPS-induced expression of pro-inflammatory cytokines in RAW 264.7 macrophages and suppresses LPS-induced activation of NF-κB[1]. 4′-Hydroxywogonin (0.5-15 μM; 1 h) suppresses LPS-induced degradation of IκB-α and activation of IKK and TAK and suppresses the phosphorylation of MAPK and AKTin in RAW 264.7 macrophages[1]. 4′-Hydroxywogonin (0.5-15 μM; 24 h) inhibits ROS production in LPS-stimulated RAW 264.7 macrophages[1]. 4′-Hydroxywogonin (0-10 μg/mL; 24 h) reduces the viability of SW620 cells in a concentration- and time-dependent manner and decreases the mRNA and protein expression of vascular endothelial growth factor-A (VEGF-A), the predominant pro-angiogenic cytokine in tumor angiogenesis[2]. 4′-Hydroxywogonin (24 h; SUP-B15 and Jurkat cells) induces apoptosis and decreases the expression of C-MYC, BCL-2 and cleaved caspase 3[3]. Cell Viability Assay[1] Cell Line: RAW 264.7 macrophages Concentration: 0.5, 5 and 15 μM Incubation Time: 24 hours Result: Had low cytotoxicity in RAW 264.7 macrophages. Western Blot Analysis[1] Cell Line: RAW 264.7 macrophages Concentration: 0.5, 5 and 15 μM Incubation Time: 1 hours Result: Attenuated the increase of iNOS and COX-2 mRNA expression induced by LPS in RAW 264.7 cells. Western Blot Analysis[1] Cell Line: RAW 264.7 macrophages Concentration: 0.5, 5 and 15 μM Incubation Time: 1 and 12 hours Result: Reduced TNF-α, IL-6 and IL-1β mRNA expression in a dose-dependent manner. Inhibited LPS-induced p65 phosphorylation and nuclear translocation. Western Blot Analysis[1] Cell Line: RAW 264.7 macrophages Concentration: 0.5, 5 and 15 μM Incubation Time: 1 hours Result: Attenuated LPS induced IκB-α degradation. Attenuated the phosphorylation of ERK1/2 and p38 in a dose-dependent manner. Reduced the intensity of the TAK1/TAB1 band. Western Blot Analysis[2] Cell Line: SW620 cells Concentration: 0.1, 1, and 10 μg/mL Incubation Time: 24 hours Result: Downregulated VEGF-Aexpression in colorectal cancer cells and suppressed angiogenesis. |
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| In Vivo | 4′-Hydroxywogonin (10 and 20 mg/kg; i.p.; male C57BL/6 mice) alleviates LPS-induced acute lung injury (ALI) in a mouse model[1]. Animal Model: Male C57BL/6 mice (6-8 weeks old; 20 g) with acute lung injury model[1] Dosage: 10 and 20 mg/kg Administration: Intraperitoneal injection, 12 and 1 h before LPS treatment Result: Had potential protective effects against inflammation in LPS induced ALI mice. Attenuated the degree of leukocyte infiltration. |
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Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
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| Boiling Point | 578.1±50.0 °C at 760 mmHg |
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| Molecular Formula | C16H12O6 |
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| Molecular Weight | 300.263 |
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| Flash Point | 220.9±23.6 °C |
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| Exact Mass | 300.063385 |
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| PSA | 100.13000 |
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| LogP | 1.37 |
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| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
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| Index of Refraction | 1.697 |
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| InChIKey | OEZZJTAJYYSQKM-UHFFFAOYSA-N |
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| SMILES | COc1c(O)cc(O)c2c(=O)cc(-c3ccc(O)cc3)oc12 |
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Safety Information
Synonyms
| 4'-Hydroxywogonin |
| isoscutellarein-8-methylether |
| 8-Methoxy-iso-scutellargin |
| 5,7,4'-trihydroxy-8-methoxyflavone |
| 4'-Hydroxywogonine |
| 4H-1-Benzopyran-4-one, 5,7-dihydroxy-2-(4-hydroxyphenyl)-8-methoxy- |
| 5,7-Dihydroxy-2-(4-hydroxyphenyl)-8-methoxy-4H-1-benzopyran-4-one |
| 5,7-Dihydroxy-2-(4-hydroxyphenyl)-8-methoxy-4H-chromen-4-one |
| isooscutellarein 8-methyl ether |
| Isoscutellarein 8-methyl ether |
| 8-methoxy-hebacetin |
