CAS 1414-39-7|albomycin

Introduction：Basic information about CAS 1414-39-7|albomycin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. albomycin BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	albomycin
CAS Number	1414-39-7	Molecular Weight	1006.81000
Density	/	Boiling Point	/
Molecular Formula	C₃₆H₅₈FeN₁₀O₁₈S	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	albomycin δ1
Synonym	More Synonyms

albomycin BiologicalActivity

Description	Albomycin is an inhibitor of aminoacyl-tRNA synthetases with Trojan-horse effect. Albomycin is delivered by iron-chelator portion into bacterial through ferrichrome-specific transporter system. Albomycin combats against a wide range of Gram-positive and Gram-negative bacteria. Albomycin also serves as an efficient iron-scavenger of producer[1].
Related Catalog	Research Areas >>InfectionSignaling Pathways >>Cell Cycle/DNA Damage >>DNA/RNA SynthesisSignaling Pathways >>Anti-infection >>Bacterial
In Vitro	Albomycin 也与 FhuA 结合，与高铁色素竞争结合位点。FhuA 是埋在大肠杆菌外膜的 β 桶。或者，Albomycin 结合 FhuD，FhuD 是细胞膜 ABC 转运蛋白 FhuB/FhuC 的质周亚基[1]。 Albomycin 对肺炎链球菌的生长有明显的抑制作用，最低抑制浓度为 4-62 nM[1]。
References	[1]. Travin DY, et al. Natural Trojan horse inhibitors of aminoacyl-tRNA synthetases. RSC Chem Biol. 2021 Feb 22;2(2):468-485.

Chemical & Physical Properties

Molecular Formula	C₃₆H₅₈FeN₁₀O₁₈S
Molecular Weight	1006.81000
Exact Mass	1006.30000
PSA	465.52000
InChIKey	NDZHMVWHFMFIEG-ZYBDUZOASA-N
SMILES	CC(=O)N(O)CCCC(N)C(=O)NC(CCCN(O)C(C)=O)C(=O)NC(CCCN(O)C(C)=O)C(=O)NC(CO)C(=O)NC(C(=O)O)C(O)C1SC(n2ccc(=O)n(C)c2=O)C(O)C1O.[Fe+3]

Synonyms

ferric 2-[[2-[[5-(acetyl-hydroxy-amino)-2-[[5-(acetyl-hydroxy-ami no)-2-[[5-(acetyl-hydroxy-amino)-2-amino-pentanoyl]amino]pentanoy l]amino]pentanoyl]amino]-3-hydroxy-propanoyl]amino]-3-[(2R,3S,4R, 5R)-3,4-dihydroxy-5-(3-methyl-2,4-dioxo

albomycin delta1

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