CAS 402473-54-5|ONO-AE3-208
Introduction：Basic information about CAS 402473-54-5|ONO-AE3-208, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | ONO-AE3-208 | ||
|---|---|---|---|
| CAS Number | 402473-54-5 | Molecular Weight | 404.434 |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 662.4±55.0 °C at 760 mmHg |
| Molecular Formula | C24H21FN2O3 | Melting Point | / |
| MSDS | / | Flash Point | 354.4±31.5 °C |
Names
| Name | 4-[4-cyano-2-[2-(4-fluoronaphthalen-1-yl)propanoylamino]phenyl]butanoic acid |
|---|---|
| Synonym | More Synonyms |
ONO-AE3-208 BiologicalActivity
| Description | ONO-AE3-208 is an EP4 antagonist, and suppresses cell invasion, migration, and metastasis of prostate cancer. |
|---|---|
| Related Catalog | Signaling Pathways >>GPCR/G Protein >>Prostaglandin ReceptorResearch Areas >>Cancer |
| Target | EP4 |
| In Vitro | ONO-AE3-208 surpresses the in vitro cell invasion and migration in a dose-dependent manner without affecting cell proliferation[1]. ONO-AE3-208 abolisheS CTGF in the presence of the EET synthesis inhibitor MS-PPOH. Arachidonic acid (AA) causeS dose-dependent dilation of the attached Af-Art, and this effect is blocked by ONO-AE3-208[2]. |
| In Vivo | ONO-AE3-208 surpresses the in vivo bone metastasis of PC3 cells in mice[1]. The photon tumor burdens are significantly increased in a time-dependent manner in the control group in comparison with those in the ONO-AE3-208-treated group. The rate of metastasis formation is significantly higher in the former than in the latter. The median time of metastasis formation is 29 d in the ONO-AE3-208-treated animals as compared with 21 d in the controls[3]. |
| References | [1]. Xu S, et al. An EP4 Antagonist ONO-AE3-208 Suppresses Cell Invasion, Migration, and Metastasis of Prostate Cancer. Cell Biochem Biophys. 2014 Apr 18. [2]. Ren Y, et al. Prostaglandin E2 mediates connecting tubule glomerular feedback. Hypertension. 2013 Dec;62(6):1123-8. [3]. Xu S, et al. Inhibitory effect of ONO-AE3-208 on the formation of bone metastasis of prostate cancer in mice. Zhonghua Nan Ke Xue. 2014 Aug;20(8):684-9. [4]. Thieme K, et al. EP4 inhibition attenuates the development of diabetic and non-diabetic experimental kidney disease. Sci Rep. 2017 Jun 13;7(1):3442. |
Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 662.4±55.0 °C at 760 mmHg |
| Molecular Formula | C24H21FN2O3 |
| Molecular Weight | 404.434 |
| Flash Point | 354.4±31.5 °C |
| Exact Mass | 404.153625 |
| PSA | 90.19000 |
| LogP | 4.56 |
| Vapour Pressure | 0.0±2.1 mmHg at 25°C |
| Index of Refraction | 1.637 |
| InChIKey | MTDIMKNAJUQTIO-UHFFFAOYSA-N |
| SMILES | CC(C(=O)Nc1cc(C#N)ccc1CCCC(=O)O)c1ccc(F)c2ccccc12 |
| Storage condition | 2-8℃ |
Synonyms
| 4-Cyano-2-[[2-(4-fluoro-1-naphthalenyl)-1-oxopropyl]amino]benzenebutanoic acid |
| ONO AE3 208 |
| 4-[4-cyano-2-[2-(4-fluoro-1-naphthyl)propanoylamino]phenyl]butanoic acid |
| 4-(4-cyano-2-(2-(4-fluoronaphthalen-1-yl)propionylamino)phenyl)butyric acid |
| ONO-AE3-208||ONO AE3 208 |
| 4-(4-Cyano-2-{[2-(4-fluoro-1-naphthyl)propanoyl]amino}phenyl)butanoic acid |
| Benzenebutanoic acid, 4-cyano-2-[[2-(4-fluoro-1-naphthalenyl)-1-oxopropyl]amino]- |
| ONO-AE3-208 |
