CAS 701232-20-4|DGAT-3

Introduction：Basic information about CAS 701232-20-4|DGAT-3, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. DGAT-3 BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	DGAT-3
CAS Number	701232-20-4	Molecular Weight	394.467
Density	1.4±0.1 g/cm3	Boiling Point	616.6±55.0 °C at 760 mmHg
Molecular Formula	C₂₂H₂₆N₄O₃	Melting Point	/
MSDS	USA	Flash Point	326.7±31.5 °C

Names

Name	2-[4-[4-(4-amino-7,7-dimethylpyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]cyclohexyl]acetic acid
Synonym	More Synonyms

DGAT-3 BiologicalActivity

Description	T-863(DGAT-1 inhibitor) is an orally active, selective and potent DGAT1 (Acyl-CoA:diacylglycerol acyltransferase 1) inhibitor that interacts with the acyl-CoA binding site of DGAT1, and inhibits triacylglycerol synthesis in cells.IC50 value:Target: DGAT1T863 causes weight loss, reduction in serum and liver triglycerides, and improved insulin sensitivity in obese mice.
Related Catalog	Signaling Pathways >>Metabolic Enzyme/Protease >>AcyltransferaseResearch Areas >>Metabolic Disease
References	[1]. Cao J, et al. Targeting Acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) with small molecule inhibitors for the treatment of metabolic diseases. J Biol Chem. 2011 Dec 2;286(48):41838-51. [2]. Dow RL, et al. Design and synthesis of potent, orally-active DGAT-1 inhibitors containing a dioxino[2,3-d]pyrimidine core. Bioorg Med Chem Lett. 2011 Oct 15;21(20):6122-5. [3]. Qian Y, et al. Discovery of orally active carboxylic acid derivatives of 2-phenyl-5-trifluoromethyloxazole-4-carboxamide as potent diacylglycerol acyltransferase-1 inhibitors for the potential treatment of obesity and diabetes. J Med Chem. 2011 Apr 14;54(

Description

T-863(DGAT-1 inhibitor) is an orally active, selective and potent DGAT1 (Acyl-CoA:diacylglycerol acyltransferase 1) inhibitor that interacts with the acyl-CoA binding site of DGAT1, and inhibits triacylglycerol synthesis in cells.IC50 value:Target: DGAT1T863 causes weight loss, reduction in serum and liver triglycerides, and improved insulin sensitivity in obese mice.

Related Catalog

Signaling Pathways >>Metabolic Enzyme/Protease >>AcyltransferaseResearch Areas >>Metabolic Disease

References

[1]. Cao J, et al. Targeting Acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) with small molecule inhibitors for the treatment of metabolic diseases. J Biol Chem. 2011 Dec 2;286(48):41838-51.

[2]. Dow RL, et al. Design and synthesis of potent, orally-active DGAT-1 inhibitors containing a dioxino[2,3-d]pyrimidine core. Bioorg Med Chem Lett. 2011 Oct 15;21(20):6122-5.

[3]. Qian Y, et al. Discovery of orally active carboxylic acid derivatives of 2-phenyl-5-trifluoromethyloxazole-4-carboxamide as potent diacylglycerol acyltransferase-1 inhibitors for the potential treatment of obesity and diabetes. J Med Chem. 2011 Apr 14;54(

Chemical & Physical Properties

Density	1.4±0.1 g/cm3
Boiling Point	616.6±55.0 °C at 760 mmHg
Molecular Formula	C₂₂H₂₆N₄O₃
Molecular Weight	394.467
Flash Point	326.7±31.5 °C
Exact Mass	394.200500
PSA	110.69000
LogP	3.06
Vapour Pressure	0.0±1.9 mmHg at 25°C
Index of Refraction	1.674
InChIKey	FUIYMYNYUHVDPT-UHFFFAOYSA-N
SMILES	CC1(C)Oc2ncnc(N)c2N=C1c1ccc(C2CCC(CC(=O)O)CC2)cc1
Storage condition	2-8℃

Safety Information

RIDADR	NONH for all modes of transport

Synonyms

DGAT-1 inhibitor

cc-141

DGAT-3

trans-4-(4-(4-amino-7,7-dimethyl-7h-pyrimido(4,5-b)(1,4)oxazin-6-yl)phenyl)cyclohexaneacetic acid

T863

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