CAS 59401-28-4|Mating Factor α acetate salt
Introduction：Basic information about CAS 59401-28-4|Mating Factor α acetate salt, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Mating Factor α acetate salt | ||
|---|---|---|---|
| CAS Number | 59401-28-4 | Molecular Weight | 1683.97000 |
| Density | 1.338 g/cm3 | Boiling Point | 1995.8ºC at 760 mmHg |
| Molecular Formula | C82H114N20O17S | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | / |
Names
| Name | α(1)-mating factor |
|---|---|
| Synonym | More Synonyms |
Mating Factor α acetate salt BiologicalActivity
| Description | α-Factor Mating Pheromone, yeast is a tridecapeptide secreted by S. cerevisiae α cells via Ste2p receptor. |
|---|---|
| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>OthersPeptides |
| Target | Ste2p[1] |
| In Vitro | α-Factor Mating Pheromone, yeast is synthesized constitutively by MATα cells and acting on MATa cells[1]. α-Factor Mating Pheromone, yeast inhibits the division cycle of yeast a cells, and competes for binding of 35S-α-factor to haploid a cells, with Kd of 0.3 μM, and this binding is related to five temperature-sensitive ste2 mutants, and is thermolabile. However, α-Factor Mating Pheromone, yeast binding activity of other temperature-sensitive mutants (ste4, ste5, ste7, ste11, and ste12) shows no thermolability[2]. |
| References | [1]. Naider F, et al. The alpha-factor mating pheromone of Saccharomyces cerevisiae: a model for studying the interaction of peptide hormones and G protein-coupled receptors. Peptides. 2004 Sep;25(9):1441-63. [2]. Jenness DD, et al. Binding of alpha-factor pheromone to yeast a cells: chemical and genetic evidence for an alpha-factor receptor. Cell. 1983 Dec;35(2 Pt 1):521-9. |
Chemical & Physical Properties
| Density | 1.338 g/cm3 |
|---|---|
| Boiling Point | 1995.8ºC at 760 mmHg |
| Molecular Formula | C82H114N20O17S |
| Molecular Weight | 1683.97000 |
| Exact Mass | 1682.84000 |
| PSA | 612.93000 |
| LogP | 6.31310 |
| Index of Refraction | 1.625 |
| InChIKey | SBKVPJHMSUXZTA-MEJXFZFPSA-N |
| SMILES | CSCCC(NC(=O)C1CCCN1C(=O)C(CCC(N)=O)NC(=O)CNC(=O)C1CCCN1C(=O)C(CCCCN)NC(=O)C(CC(C)C)NC(=O)C(CCC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)C(Cc1cnc[nH]1)NC(=O)C(N)Cc1c[nH]c2ccccc12)C(=O)NC(Cc1ccc(O)cc1)C(=O)O |
| Storage condition | −20°C |
| Water Solubility | H2O: 1 mg/mL, clear, colorless | Soluble in water at 1mg/ml |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Safety Phrases | S22-S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
Articles2
More Articles| Synthesis of the mating factor of Saccharomyces cerevisiae and its truncated peptides : the structure-activity relationship. Biochem. Biophys. Res. Commun. 78 , 534, (1977) | |
| Gcn5p plays an important role in centromere kinetochore function in budding yeast. Mol. Cancer Ther. 28 , 988-96, (2008) We report that the histone acetyltransferase Gcn5p is involved in cell cycle progression, whereas its absence induces several mitotic defects, including inefficient nuclear division, chromosome loss, ... |
Synonyms
| alpha1-Mating Factor acetate salt |
| alpha1-MATING FACTOR |
| MFCD00133883 |
| Trp-His-Trp-Leu-Gln-Leu-Lys-Pro-Gly-Gln-Pro-Met-Tyr |
| A1-Mating Factor acetate salt |
| WHWLQLKPGQPMY |
| α-Factor Mating Pheromone, yeast |
