CAS 1949-45-7|Metrizoic acid

Introduction：Basic information about CAS 1949-45-7|Metrizoic acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Metrizoic acid BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Customs
7. Synonyms

Common Name	Metrizoic acid
CAS Number	1949-45-7	Molecular Weight	627.94000
Density	2.483g/cm3	Boiling Point	678.8ºC at 760mmHg
Molecular Formula	C₁₂H₁₁I₃N₂O₄	Melting Point	/
MSDS	/	Flash Point	364.3ºC

Names

Name	metrizoic acid
Synonym	More Synonyms

Metrizoic acid BiologicalActivity

Description	Metrizoic acid (Metrizoate) is an ionic contrast medium. Metrizoic acid (Metrizoate) shows high osmolality and has a risk of inducing allergic reactions[1][2][3].
Related Catalog	Research Areas >>OthersSignaling Pathways >>Others >>Others
References	[1]. Vik-Mo H, et al. Hemodynamic and electrocardiographic consequences of high- and low-osmolality contrast agents for left ventricular angiography. Cathet Cardiovasc Diagn. 1988;14(3):143-9. [2]. Sortland O, et al. Iopentol in urography. A clinical comparison between iopentol and metrizoate includingdelayed reactions. Acta Radiol. 1992 Jul;33(4):368-73. [3]. Holtås S,et al. Contrast enhanced brain CT. Comparison between iohexol and metrizoate. Neuroradiology. 1983;24(4):213-5.

Description

Metrizoic acid (Metrizoate) is an ionic contrast medium. Metrizoic acid (Metrizoate) shows high osmolality and has a risk of inducing allergic reactions[1][2][3].

Related Catalog

Research Areas >>OthersSignaling Pathways >>Others >>Others

References

[1]. Vik-Mo H, et al. Hemodynamic and electrocardiographic consequences of high- and low-osmolality contrast agents for left ventricular angiography. Cathet Cardiovasc Diagn. 1988;14(3):143-9.

[2]. Sortland O, et al. Iopentol in urography. A clinical comparison between iopentol and metrizoate includingdelayed reactions. Acta Radiol. 1992 Jul;33(4):368-73.

[3]. Holtås S,et al. Contrast enhanced brain CT. Comparison between iohexol and metrizoate. Neuroradiology. 1983;24(4):213-5.

Chemical & Physical Properties

Density	2.483g/cm3
Boiling Point	678.8ºC at 760mmHg
Molecular Formula	C₁₂H₁₁I₃N₂O₄
Molecular Weight	627.94000
Flash Point	364.3ºC
Exact Mass	627.78500
PSA	86.71000
LogP	3.21270
Vapour Pressure	2.35E-19mmHg at 25°C
Index of Refraction	1.77
InChIKey	GGGDNPWHMNJRFN-UHFFFAOYSA-N
SMILES	CC(=O)Nc1c(I)c(C(=O)O)c(I)c(N(C)C(C)=O)c1I

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DG0887300

CHEMICAL NAME :: Benzoic acid, 3-acetamido-2,4,6-triiodo-5-(N-methylacetamido)-

CAS REGISTRY NUMBER :: 1949-45-7

LAST UPDATED :: 199612

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C12-H11-I3-N2-O4

MOLECULAR WEIGHT :: 627.95

WISWESSER LINE NOTATION :: 1VN1&R BI DI FI CVQ EMV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 38100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,843,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 29600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,843,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 14300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,843,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >46800 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,843,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 36 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,843,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 17,340,1962

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intracerebral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 234 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,843,1982

Safety Information

Risk Phrases	36/37/38
Safety Phrases	S26-S36/37/39
RTECS	DG0887300
HS Code	2924299090

Customs

HS Code	2924299090
Summary	2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Synonyms

3-Acetamido-2,4,6-triiodo-5-(N-methylacetamido)benzoic acid

Metrizoic acid

metrizoate

3-Acetamido-5-(N-methylacetamido)-2,4,6-triiodobenzoic Acid

3,5-DiacetaMido-N-Methyl-2,4,6-triiodobenzoic Acid

Metrizoic

Metrizoesaeure

MFCD00867964

Triosil-280

5-Acetamino-3-<N-acetyl-methylamino>-2.4.6-triiod-benzoesaeure

EINECS 217-761-1

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