CAS 80629-35-2|Captopril EP Impurity B

Introduction：Basic information about CAS 80629-35-2|Captopril EP Impurity B, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Captopril EP Impurity B BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Captopril EP Impurity B
CAS Number	80629-35-2	Molecular Weight	264.11600
Density	1.555±0.06 g/cm3 (20 ºC 760 Torr)	Boiling Point	/
Molecular Formula	C₉H₁₄BrNO₃	Melting Point	110-114 ºC
MSDS	/	Flash Point	/

Names

Name	1-(3-bromo-2S-methylpropionyl)-pyrrolidine-2S-carboxylic acid
Synonym	More Synonyms

Captopril EP Impurity B BiologicalActivity

Description	Captopril EP Impurity B is an impurity of Captopril. Captopril (SQ-14534), antihypertensive agent, is a thiol-containing competitive, orally active angiotensin-converting enzyme (ACE) inhibitor (IC50=0.025 μM)[1][2][3].
Related Catalog	Research Areas >>OthersSignaling Pathways >>Others >>Others
References	[1]. ANCA GABRIELA CÂRJE, et al. HPLC-UV METHOD APPROACH FOR THE ANALYSIS AND IMPURITY PROFILING OF CAPTOPRIL. [2]. Afrin S, et al. Eritadenine from Edible Mushrooms Inhibits Activity of Angiotensin Converting Enzyme in Vitro. J Agric Food Chem. 2016;64(11):2263-2268. [3]. Esmaeili S, et al. Captopril/enalapril inhibit promiscuous esterase activity of carbonic anhydrase at micromolar concentrations: An in vitro study. Chem Biol Interact. 2017;265:24-35.

Description

Captopril EP Impurity B is an impurity of Captopril. Captopril (SQ-14534), antihypertensive agent, is a thiol-containing competitive, orally active angiotensin-converting enzyme (ACE) inhibitor (IC50=0.025 μM)[1][2][3].

Related Catalog

Research Areas >>OthersSignaling Pathways >>Others >>Others

References

[1]. ANCA GABRIELA CÂRJE, et al. HPLC-UV METHOD APPROACH FOR THE ANALYSIS AND IMPURITY PROFILING OF CAPTOPRIL.

[2]. Afrin S, et al. Eritadenine from Edible Mushrooms Inhibits Activity of Angiotensin Converting Enzyme in Vitro. J Agric Food Chem. 2016;64(11):2263-2268.

[3]. Esmaeili S, et al. Captopril/enalapril inhibit promiscuous esterase activity of carbonic anhydrase at micromolar concentrations: An in vitro study. Chem Biol Interact. 2017;265:24-35.

Chemical & Physical Properties

Density	1.555±0.06 g/cm3 (20 ºC 760 Torr)
Melting Point	110-114 ºC
Molecular Formula	C₉H₁₄BrNO₃
Molecular Weight	264.11600
Exact Mass	263.01600
PSA	57.61000
LogP	1.03090
InChIKey	SJYSAVFKJLHJHP-RQJHMYQMSA-N
SMILES	CC(CBr)C(=O)N1CCCC1C(=O)O

Synonyms

1-[(2S)-3-Bromo-2-methyl-1-oxopropyl]-L-proline

Captopril EP Impurity B

Captopril Impurity 2

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