Introduction：Basic information about CAS 950736-05-7|B-Raf IN 1, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | B-Raf IN 1 |
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| CAS Number | 950736-05-7 | Molecular Weight | 515.529 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | / |
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| Molecular Formula | C29H24F3N5O | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | Benzamide, N-[3-[3-[4-[(dimethylamino)methyl]phenyl]pyrazolo[1,5-a]pyrimidin-7-yl]phenyl]-3-(trifluoromethyl) |
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| Synonym | More Synonyms |
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B-Raf IN 1 BiologicalActivity
| Description | B-Raf IN 1 is a potent and selective B-Raf kinase inhibitor with an IC50 of 24 nM. |
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| Related Catalog | Research Areas >>Cancer |
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| Target | B-Raf:24 nM (IC50) |
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| In Vitro | B-Raf IN 1 (Compound 10n) inhibits WM 266-4 and HT29 cells with IC50s of 0.92 and 0.78 μM, respectively[1]. |
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| References | [1]. Berger DM, et al. Non-hinge-binding pyrazolo[1,5-a]pyrimidines as potent B-Raf kinase inhibitors. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6519-23. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Molecular Formula | C29H24F3N5O |
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| Molecular Weight | 515.529 |
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| Exact Mass | 515.193298 |
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| PSA | 62.53000 |
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| LogP | 4.39 |
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| Appearance of Characters | yellow solid |
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| Index of Refraction | 1.621 |
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| InChIKey | AIWJVLQNYNCDSL-UHFFFAOYSA-N |
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| SMILES | CN(C)Cc1ccc(-c2cnn3c(-c4cccc(NC(=O)c5cccc(C(F)(F)F)c5)c4)ccnc23)cc1 |
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| Storage condition | -20℃ |
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Synonyms
| N-[3-(3-{4-[(Dimethylamino)methyl]phenyl}pyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-3-(trifluoromethyl)benzamide |
| Benzamide, N-[3-[3-[4-[(dimethylamino)methyl]phenyl]pyrazolo[1,5-a]pyrimidin-7-yl]phenyl]-3-(trifluoromethyl)- |
| B-Raf IN 1 |
