CAS 21770-81-0|1-Methylguanidine hydrochloride

Introduction：Basic information about CAS 21770-81-0|1-Methylguanidine hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Chemical & Physical Properties
3. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
4. Safety Information
5. Preparation
6. Articles4
7. Synonyms

Common Name	1-Methylguanidine hydrochloride
CAS Number	21770-81-0	Molecular Weight	109.55800
Density	1.22 g/mL at 20 °C(lit.)	Boiling Point	72 °C
Molecular Formula	C₂H₈ClN₃	Melting Point	-20 °C
MSDS	ChineseUSA	Flash Point	65 °F
Symbol	GHS07	Signal Word	Warning

Names

Name	2-methylguanidine,hydrochloride
Synonym	More Synonyms

Chemical & Physical Properties

Density	1.22 g/mL at 20 °C(lit.)
Boiling Point	72 °C
Melting Point	-20 °C
Molecular Formula	C₂H₈ClN₃
Molecular Weight	109.55800
Flash Point	65 °F
Exact Mass	109.04100
PSA	61.90000
LogP	1.09220
Index of Refraction	n20/D 1.4279(lit.)
Water Solubility	insoluble

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MF3990000

CHEMICAL NAME :: Guanidine, 1-methyl-, hydrochloride

CAS REGISTRY NUMBER :: 21770-81-0

LAST UPDATED :: 199009

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C2-H7-N3.Cl-H

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 375 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 28,251,1926

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 680 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CKFRAY Ceskoslovenska Farmacie. (PNS-Ustredni Expedice a Dovoz Tisku, Kafkova 19, 160 00 Prague 6, Czechoslovakia) V.1- 1952- Volume(issue)/page/year: 1,434,1952

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 18 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#04013

Safety Information

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H315-H319
Precautionary Statements	P280-P301 + P312 + P330-P305 + P351 + P338-P337 + P313
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn: Harmful;
Risk Phrases	R22
Safety Phrases	S26-S36/37
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	MF3990000

Preparation

Articles4

Organic anion transporting polypeptides 1B1 and 1B3 play an important role in uremic toxin handling and drug-uremic toxin interactions in the liver.

J. Pharm. Pharm. Sci. 17(4) , 475-84, (2015)

Organic anion-transporting polypeptide (OATP) 1B1 and OATP1B3 contribute to hepatic uptake of numerous drugs. Thus, reduced OATP1B1 and OATP1B3 activity in chronic kidney disease (CKD) may have a majo...

Structure and dynamics of a salt-bridge model system in water and DMSO.

J. Chem. Phys. 142 , 212436, (2015)

We study the interaction between the ions methylguanidinium and trifluoroacetate dissolved in D2O and dimethylsulfoxide with linear infrared spectroscopy and femtosecond two-dimensional infrared spect...

In-vitro evidence of enhanced breast cancer resistance protein-mediated intestinal urate secretion by uremic toxins in Caco-2 cells.

J. Pharm. Pharmacol. 67(2) , 170-7, (2015)

It has been reported that intestinal urate excretion is increased at chronic kidney disease (CKD) state. In this report, whether uremic toxins are involved in the upregulation of intestinal breast can...

Synonyms

1-Methylguanidine hydrochloride

1-Methylguanidine HCl

2-methylguanidine hydrochloride

Methylguanidine HCl

Methylguanidinehydrochloride

MFCD00012576

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