Introduction：Basic information about CAS 1162656-22-5|MCB-613, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | MCB-613 |
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| CAS Number | 1162656-22-5 | Molecular Weight | 304.386 |
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| Density | 1.159±0.06 g/cm3 | Boiling Point | 510.4±50.0 °C at 760 mmHg |
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| Molecular Formula | C20H20N2O | Melting Point | / |
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| MSDS | / | Flash Point | 257.9±36.5 °C |
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Names
| Name | 4-ethyl-2,6-bis(pyridin-3-ylmethylene)cyclohexanone |
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| Synonym | More Synonyms |
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MCB-613 BiologicalActivity
| Description | MCB-613 is a potent, pan steroid receptor coactivator (SRC) stimulator.Target: SRCin vitro: MCB-613 exerts the greatest activation of SRC-1 in the primary screen, is confirmed to be a strong activator of all three SRCs. MCB-613 can super-stimulate SRCs' transcriptional activity. MCB-613 increases SRCs' interactions with other coactivators and markedly induces ER stress coupled to the generation of reactive oxygen species (ROS). MCB-613 selectively and reversibly binds to the RID of SRC-3, and selectively kills cancer cells including MCF-7 (breast), PC-3 (prostate), H1299 (lung), and HepG2 (liver) cells, without toxicity to mouse primary hepatocytes and mouse embryonic fibroblasts (MEFs). MCB-613 also increases SRCs' interactions with other coactivators and markedly induces ER stress coupled to the generation of reactive oxygen species (ROS). [1]in vivo: In an MCF-7 breast cancer mouse xenograft model, MCB-613 (20 mg/kg, i.p.) significantly and dramatically inhibits the growth of the tumor while causing no obvious animal toxicity and body weight less. [1] |
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| Related Catalog | Signaling Pathways >>Protein Tyrosine Kinase/RTK >>SrcResearch Areas >>Cancer |
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| References | [1]. Wang L, et al. Characterization of a Steroid Receptor Coactivator Small Molecule Stimulator that Overstimulates Cancer Cells and Leads to Cell Stress and Death. Cancer Cell. 2015 Aug 10;28(2):240-52. |
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Chemical & Physical Properties
| Density | 1.159±0.06 g/cm3 |
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| Boiling Point | 510.4±50.0 °C at 760 mmHg |
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| Molecular Formula | C20H20N2O |
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| Molecular Weight | 304.386 |
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| Flash Point | 257.9±36.5 °C |
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| Exact Mass | 304.157562 |
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| PSA | 42.85000 |
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| LogP | 4.55 |
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| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
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| Index of Refraction | 1.640 |
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| InChIKey | MMBSCBVEHMETSA-GDAWTGGTSA-N |
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| SMILES | CCC1CC(=Cc2cccnc2)C(=O)C(=Cc2cccnc2)C1 |
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| Storage condition | -20℃ |
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| Water Solubility | Practically insoluble (0.061 g/L) (25 ºC) |
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Synonyms
| (2E,6E)-4-Ethyl-2,6-bis(3-pyridinylmethylene)cyclohexanone |
| Cyclohexanone, 4-ethyl-2,6-bis(3-pyridinylmethylene)-, (2E,6E)- |
| MCB-613 |
