CAS 26530-20-1|2-Octyl-2H-isothiazol-3-one

CHEMICAL IDENTIFICATION

RTECS NUMBER :

NX8156900

CHEMICAL NAME :

4-Isothiazolin-3-one, 2-octyl-

CAS REGISTRY NUMBER :

26530-20-1

LAST UPDATED :

199710

DATA ITEMS CITED :

10

MOLECULAR FORMULA :

C11-H19-N-O-S

MOLECULAR WEIGHT :

213.37

WISWESSER LINE NOTATION :

T5SNVJ B8

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

Standard Draize test

ROUTE OF EXPOSURE :

Administration onto the skin

SPECIES OBSERVED :

Rodent - rabbit

REFERENCE :

MosJN# Personal Communication from J.N. Moss, Toxicology Dept., Rohm and Haas Co., Spring House, PA 19477, Aug. 15, 1979 Volume(issue)/page/year: 15AUG1979

TYPE OF TEST :

Standard Draize test

ROUTE OF EXPOSURE :

Administration into the eye

SPECIES OBSERVED :

Rodent - rabbit

REFERENCE :

MosJN# Personal Communication from J.N. Moss, Toxicology Dept., Rohm and Haas Co., Spring House, PA 19477, Aug. 15, 1979 Volume(issue)/page/year: 15AUG1979 ** ACUTE TOXICITY DATA **

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

550 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

MosJN# Personal Communication from J.N. Moss, Toxicology Dept., Rohm and Haas Co., Spring House, PA 19477, Aug. 15, 1979 Volume(issue)/page/year: 15AUG1979

TYPE OF TEST :

LC - Lethal concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

>2 gm/m3

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

JALCAQ Journal of the American Leather Chemists' Association. (American Leather Chemists' Association, Tanners' Council Research Laboratory, Room 10, Campus Station, Cincinnati, OH 45221) V.1- 1906- Volume(issue)/page/year: 74,322,1979

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Administration onto the skin

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

690 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

MosJN# Personal Communication from J.N. Moss, Toxicology Dept., Rohm and Haas Co., Spring House, PA 19477, Aug. 15, 1979 Volume(issue)/page/year: 15AUG1979 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1443 No. of Facilities: 237 (estimated) No. of Industries: 4 No. of Occupations: 7 No. of Employees: 2782 (estimated) No. of Female Employees: 23 (estimated)

Contact Dermatitis 50(1) , 47-8, (2004)

Contact Dermatitis 9(6) , 507-9, (1983)

Severe allergic contact dermatitis from a paint mildewcide, 2-n-octyl-4-isothiazolin-3-one, developed in a worker formulating latex paints within a paint manufacturing company, Guinea pig maximization...

Derm. Beruf Umwelt. 32(6) , 208-11, (1984)

Observations concerning contact dermatitis to derivatives of isothiazolin-3-one are reported. A systematic review of the literature of previously published cases is reported. A verified contact dermat...