| Description | Xanthopterin, an unconjugated pteridine compound, is the main component of the yellow granule in the Oriental hornet bear wings, produces a characteristic excitation/emission maximum at 386/456 nm[2]. Xanthopterin (XPT) causes renal growth and hypertrophy in rat[1].Xanthopterin inhibits RNA synthesis[4]. |
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| Related Catalog | Research Areas >>InfectionSignaling Pathways >>Cell Cycle/DNA Damage >>DNA/RNA Synthesis |
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| In Vitro | Xanthopterin (7.8-250 mM; 24 hours) show a significant reduction in mitochondrial activity with respect to controls (IC50=109 mM)[2]. Cell Viability Assay[2] Cell Line: MCF-7 cells Concentration: 7.8 mM-250 mM Incubation Time: 24 hours Result: Resulted in reduction in mitochondrial activity. |
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| References | [1]. Xanthopterin (XPT), an unconjugated pteridine compound, affects cell growth and differentiation. When injected into rats, XPT has caused changes that have been interpreted as renal growth and hypertrophy. [2]. Lord JL, et al. Cytotoxicity of xanthopterin and isoxanthopterin in MCF-7 cells. Cancer Lett. 2005 May 10;222(1):119-24. [3]. Plotkin M, et al. Xanthopterin in the Oriental hornet (Vespa orientalis): light absorbance is increased with maturation of yellow pigment granules. Photochem Photobiol. 2009 Jul-Aug;85(4):955-61. [4]. Ziegler I, et al. Pterins and the regulation of lymphocyte activation on the mode of xanthopterin action. Hoppe Seylers Z Physiol Chem. 1984 Jun;365(6):667-73. |
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| 2-aminopteridine-4(3H),6(5H)-dione |
| 4,6-Pteridinedione,2-amino-1,5-dihydro-(9CI) |
| 4,6-pteridinediol, 2-amino- |
| Xanthopterin |
| 2-amino-3,5-dihydro-pteridine-4,6-dione |
| 2-amino-1,5-dihydropteridine-4,6-quinone |
| Uropterin |
| 2-amino-3,5-dihydropteridine-4,6-dione |
| 4,6-Pteridinedione, 2-amino-1,5-dihydro- |
| 6(2H)-Pteridinone, 1,5-dihydro-4-hydroxy-2-imino- |
| 2-AMINO-1,5-DIHYDROPTERIDINE-4,6-DIONE |
| 4-Hydroxy-2-imino-1,5-dihydro-6(2H)-pteridinone |
| EINECS 204-325-0 |
| 2-Amino-3,5-dihydro-pteridin-4,6-dion |
| 4(1H)-pteridinone, 2,3-dihydro-6-hydroxy-2-imino- |
| 2-Amino-1,5-dihydro-4,6-pteridinedione |
| 6-Hydroxy-2-imino-2,3-dihydropteridin-4(1H)-one |
| 2-Amino-4-oxo-6-hydroxy-3,4-dihydropteridine |
| 2-Aminopteridine-4,6-diol |
| 2-azanyl-1,5-dihydropteridine-4,6-dione |
| 2-AMINO-4,6-DIHYDROXYPTERIDENE |
| 2-Amino-4,6(1H,5H)-pteridinedione |
| MFCD00151242 |
| xanthopterine |
