Introduction：Basic information about CAS 20261-38-5|Ginkgolic acid C13:0, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Ginkgolic Acid (C13:0) is a natural anticariogenic agent in that it exhibits antimicrobial activity against S. mutans and suppresses the specific virulence factors associated with its cariogenicity.IC50 value: Inhibiting the biofilm formation of S. mutans (MBIC (50) = 4 μg/mL); reduced 1-day-developed biofilm of S. mutans by 50 % or more at low concentration (MBRC (50) = 32 μg/mL).Target:In vitro: Ginkgolic Acid (C13:0) inhibited not only the growth of S. mutans planktonic cells at minimum inhibitory concentration (MIC) of 4 μg/mL and minimum bactericidal concentration (MBC) of 8 μg/mL but also the acid production and adherence to saliva-coated hydroxyapatite of S. mutans at sub-MIC concentration. In addition, this agent was effective in inhibiting the biofilm formation of S. mutans (MBIC (50) = 4 μg/mL), and it reduced 1-day-developed biofilm of S. mutans by 50 % or more at low concentration (MBRC (50) = 32 μg/mL). Furthermore Ginkgolic Acid (C13:0) disrupted biofilm integrity effectively [1]. In vivo:
Related Catalog
Signaling Pathways >>Others >>Others
References
[1]. He J, et al. Effects of ginkgoneolic acid on the growth, acidogenicity, adherence, and biofilm of Streptococcus mutans in vitro. Folia Microbiol (Praha). 2013 Mar;58(2):147-53.
Chemical & Physical Properties
Density
1.0±0.1 g/cm3
Boiling Point
449.5±33.0 °C at 760 mmHg
Molecular Formula
C20H32O3
Molecular Weight
320.466
Flash Point
239.8±21.9 °C
Exact Mass
320.235138
PSA
57.53000
LogP
8.90
Vapour Pressure
0.0±1.2 mmHg at 25°C
Index of Refraction
1.519
InChIKey
VEPUCZUJLKAVNM-UHFFFAOYSA-N
SMILES
CCCCCCCCCCCCCc1cccc(O)c1C(=O)O
Storage condition
2-8°C
Toxicological Information
CHEMICAL IDENTIFICATION
RTECS NUMBER :
DH2944000
CHEMICAL NAME :
Benzoic acid, 2-hydroxy-6-tridecyl-
CAS REGISTRY NUMBER :
20261-38-5
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C20-H32-O3
MOLECULAR WEIGHT :
320.52
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>481 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AGACBH Agents and Actions, A Swiss Journal of Pharmacology. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1969/70- Volume(issue)/page/year: 10,361,1980
Safety Information
Symbol
GHS07
Signal Word
Warning
Hazard Statements
H315-H319-H335
Precautionary Statements
P261-P305 + P351 + P338
Hazard Codes
Xi
Risk Phrases
36/37/38
Safety Phrases
26
RIDADR
NONH for all modes of transport
HS Code
29163990
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