CAS 40615-39-2|5'-O-Dimethoxytrityl-deoxythymidine

Introduction：Basic information about CAS 40615-39-2|5'-O-Dimethoxytrityl-deoxythymidine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. 5'-O-Dimethoxytrityl-deoxythymidine BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Customs
6. Articles6
7. Synonyms

Common Name	5'-O-Dimethoxytrityl-deoxythymidine
CAS Number	40615-39-2	Molecular Weight	528.596
Density	1.2±0.1 g/cm3	Boiling Point	/
Molecular Formula	C₃₁H₃₂N₂O₇	Melting Point	114-116 °C (subl.)(lit.)
MSDS	ChineseUSA	Flash Point	/

Names

Name	5'-O-(4,4'-Dimethoxytrityl)thymidine
Synonym	More Synonyms

5'-O-Dimethoxytrityl-deoxythymidine BiologicalActivity

Description	5'-O-DMT-dT (5'-O-(4,4'-Dimethoxytrityl)thymidine) is a nucleoside derivative which can be used in the preparation of oligonucleotides[1].
Related Catalog	Signaling Pathways >>Cell Cycle/DNA Damage >>DNA/RNA SynthesisResearch Areas >>Others
References	[1]. Lars Holmberg. Method and means for oligonucleotide synthesis. WO1992009615A1.

Chemical & Physical Properties

Density	1.2±0.1 g/cm3
Melting Point	114-116 °C (subl.)(lit.)
Molecular Formula	C₃₁H₃₂N₂O₇
Molecular Weight	528.596
Exact Mass	528.226013
PSA	112.01000
LogP	6.97
Index of Refraction	1.596
InChIKey	UBTJZUKVKGZHAD-UPRLRBBYSA-N
SMILES	COc1ccc(C(OCC2OC(n3cc(C)c(=O)[nH]c3=O)CC2O)(c2ccccc2)c2ccc(OC)cc2)cc1
Storage condition	−20°C
Stability	Store in Freezer

Safety Information

Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	29349990

Customs

HS Code	29349990

Articles6

Solid-phase synthesis of polynucleotides. II. Synthesis of polythymidylic acids by the block coupling phosphotriester method.

Nucleic Acids Res. 8(22) , 5473-89, (1980)

Synthesis of two oligothymidylic acids, tridecamer and nonadecamer, is described by a rapid and simple solid-phase method on two kinds of polyacrylamide supports derivatized from commercially availabl...

Synthesis of mixed oligodeoxyribonucleotides following the solid phase method.

Nucleic Acids Res. 10(10) , 3291-301, (1982)

A method for the synthesis of mixed dimers, trimers and oligonucleotides on a solid support using monomeric protected nucleoside phosphochloridites (1a-d) has been developed and the different nucleosi...

Synthesis of 14 C-radiolabeled oligonucleotides with a novel phosphoramidite reagent.

Bioorg. Med. Chem. Lett. 8(9) , 1123-6, (1998)

A novel solid-phase synthesis of 5'-radiolabeled oligonucleotides is described. The labeling reaction is carried out by the phosphoramidite method with the aid of [4,6-di-14C]-5'-dimethoxytritylthymid...

Synonyms

Thymidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-

5'-O-dimethyltritylthymidine

5'-O-(Bis(4-methoxyphenyl)phenylmethyl)thymidine

EINECS 255-003-1

2,4(1H,3H)-pyrimidinedione, 1-[5-O-[bis(4-methoxyphenyl)phenylmethyl]-2-deoxy-β-D-glycero-pentofuranosyl]-5-methyl-

2,4(1H,3H)-Pyrimidinedione, 5-methyl-1-[(2R,5S)-tetrahydro-5-[1-methoxy-1-(methyldioxy)-2,2,2-triphenylethyl]-2-furanyl]-

1-{5-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-2-deoxy-β-D-glycero-pentofuranosyl}-5-methylpyrimidine-2,4(1H,3H)-dione

MFCD00010113

5′-O-(4,4′-Dimethoxytrityl)thymidine

5'-O-Dimethoxytrityl-deoxythymidine

1-[(2R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-hydroxyoxolan-2-yl]-5-methylpyrimidine-2,4-dione

DMTr-dThd

5‘-O-Dimethoxytrityl-deoxythymidine

5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]thymidine

1-{(2R,5S)-5-[1-Methoxy-1-(methylperoxy)-2,2,2-triphenylethyl]tetrahydro-2-furanyl}-5-methyl-2,4(1H,3H)-pyrimidinedione

Recommended......