CAS 42553-65-1|Crocin
Introduction：Basic information about CAS 42553-65-1|Crocin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Crocin | ||
|---|---|---|---|
| CAS Number | 42553-65-1 | Molecular Weight | 976.965 |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 1169.0±65.0 °C at 760 mmHg |
| Molecular Formula | C44H64O24 | Melting Point | 186° (effervescence) |
| MSDS | ChineseUSA | Flash Point | 337.8±27.8 °C |
Names
| Name | Crocin (Gardenia Fruits Extract) |
|---|---|
| Synonym | More Synonyms |
Crocin BiologicalActivity
| Description | Crocin is a nutraceutical and the main constituent isolated from the stigmas of Crocus sativus with immense pharmacological properties as anti-inflammatory, anticancer, antidepressant and anticonvulsant[1]. |
|---|---|
| Related Catalog | Research Areas >>CancerSignaling Pathways >>Others >>OthersResearch Areas >>Inflammation/ImmunologyResearch Areas >>Neurological Disease |
| References | [1]. Zaghloul MS, et al. Crocin attenuates lung inflammation and pulmonary vascular dysfunction in a rat model of bleomycin-induced pulmonary fibrosis. Life Sci. 2019 Aug 26:116794. |
Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 1169.0±65.0 °C at 760 mmHg |
| Melting Point | 186° (effervescence) |
| Molecular Formula | C44H64O24 |
| Molecular Weight | 976.965 |
| Flash Point | 337.8±27.8 °C |
| Exact Mass | 976.378723 |
| PSA | 391.20000 |
| LogP | -0.83 |
| Vapour Pressure | 0.0±0.6 mmHg at 25°C |
| Index of Refraction | 1.650 |
| InChIKey | SEBIKDIMAPSUBY-AWBRESQISA-N |
| SMILES | CC(C=CC=C(C)C(=O)OC1OC(COC2OC(CO)C(O)C(O)C2O)C(O)C(O)C1O)=CC=CC=C(C)C=CC=C(C)C(=O)OC1OC(COC2OC(CO)C(O)C(O)C2O)C(O)C(O)C1O |
| Storage condition | 2-8°C |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 10 gm/kg
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - altered sleep time (including change in righting reflex) Behavioral - changes in motor activity (specific assay)
- REFERENCE :
- JJPAAZ Japanese Journal of Pharmacology. (Japanese Pharmacological Soc., c/o Dept. of Pharmacology, Faculty of Medicine, Kyoto Univ., Sakyo-ku, Kyoto 606, Japan) V.1- 1951- Volume(issue)/page/year: 4,69,1954
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xi |
| Safety Phrases | 24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | HL7380000 |
| HS Code | 32129000 |
Articles50
More Articles| Gastroprotective effect of crocin in ethanol-induced gastric injury in rats. Chem. Biol. Interact. 229 , 26-35, (2015) The present study investigated the gastroprotective effect of crocin in ethanol-induced gastric injury in rats. Rats were allocated into a normal group, an ulcer group, a crocin-treated group, an ulce... | |
| The Gardenia jasminoides extract and its constituent, geniposide, elicit anti-allergic effects on atopic dermatitis by inhibiting histamine in vitro and in vivo. J. Ethnopharmacol. 156 , 33-40, (2014) Gardenia jasminoides Ellis has been used in traditional medicine for treatment of inflammation, edema, and dermaitis. The aim of this study was to investigate the mechanism by which Gardenia jasminoid... | |
| Crocin prevents sesamol-induced oxidative stress and apoptosis in human platelets. J. Thromb. Thrombolysis 38(3) , 321-30, (2014) Recent studies have reported the platelet proapoptotic propensity of plant-derived molecules such as, resveratrol, thymoquinone, andrographolide and gossypol. Meanwhile, there were also reports of phy... |
Synonyms
| Crocetin digentiobiose ester |
| Bis[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-({[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}methyl)tetrahydro-2H-pyran-2-yl] (2E,4E,6E,8E,10E,12E,14E)-2,6,11,15-tetramethyl-2,4,6,8,10,12,14-hexadecaheptaenedioate |
| EINECS 255-881-6 |
| MFCD00017495 |
| Bis[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-({[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}methyl)tetrahydro-2H-pyran-2-yl] (2E,4E,6E,8E,10E,12E,14E)-2,6,11,15-tetramethylhexadeca-2,4,6,8,10,12,14-heptaenedioate (non-preferred name) |
| CROCIN |
| 8,8'-Diapo-y,y-carotenedioic acid bis(6-O-b-D-glucopyranosyl-b-D-glucopyranosyl) ester |
| Digentiobiosyl 8,8'-Diapo-8,8'-carotenedioate |
| Crocetin Digentiobiosyl Ester (Gardenia Fruits Extract) |
| a-Crocin |
| Bis[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-({[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}methyl)tetrahydro-2H-pyran-2-yl] (2E,4E,6E,8E,10E,12E,14E)-2,6,11,15-tetramethyl-2,4,6,8,10,12,14-hexadecaheptaenedioate (non-preferred name) |
| Crocetin Digentiobiosyl Ester |
| Crocin 1 |
