Introduction：Basic information about CAS 1198-77-2|Sodium Urate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Uric acid sodium, scavenger of oxygen radical, is a very important antioxidant that help maintains the stability of blood pressure and antioxidant stress. Uric acid sodium can remove reactive oxygen species (ROS) such as singlet oxygen and peroxynitrite, inhibiting lipid peroxidation[1][2].
Related Catalog
Research Areas >>Metabolic Disease
Target
Human Endogenous Metabolite
In Vitro
Uric acid (400 μM; 48 hours) protects Caco-2 cells from indomethacin-induced lipid peroxidation[2]. Co-treatment of cells with Indomethacin and Uric acid (200 μM IND plus 400 μM UA; 24 hours) significantly decreases ROS levels compared to those in cells incubated with indomethacin alone. Cell viability in Caco-2 cells treated with both Indomethacin and Uric acid (200 μM IND plus 400 μM UA; 24 hours) is higher than that in cells treated with indomethacin alone. Uric acid has a protective effect on indomethacin-induced intestinal cell changes through its antioxidant activity[2].
In Vivo
Uric acid (250 mg/kg; p.o.) ameliorates indomethacin-induced enteropathy[2]. Oral administration of uric acid decreased ROS accumulation in the ileum in a mouse model of indomethacin-induced enteropathy[2]. Animal Model: Eight-week-old male C57BL/6J mice[2] Dosage: 250 mg/kg body weight Administration: P.o. Result: When mice treated with indomethacin were concurrently administered uric acid orally, ulcer areas were significantly reduced, in a uric acid dose-dependent manner.
References
[1]. Yasutake Y, et al. Uric acid ameliorates indomethacin-induced enteropathy in mice through its antioxidant activity. J Gastroenterol Hepatol. 2017;32(11):1839-1845.
[2]. Wang Q, et al. Recent Progress on Uric Acid Detection: A Review. Crit Rev Anal Chem. 2020;50(4):359-375.
Chemical & Physical Properties
Molecular Formula
C5H3N4NaO3
Molecular Weight
190.092
Exact Mass
190.010284
PSA
117.46000
InChIKey
NAFSTSRULRIERK-UHFFFAOYSA-M
SMILES
O=c1[n-]c2[nH]c(=O)[nH]c(=O)c2[nH]1.[Na+]
Stability
Stable.
Toxicological Information
CHEMICAL IDENTIFICATION
RTECS NUMBER :
YU7062000
CHEMICAL NAME :
Uric acid, monosodium salt
CAS REGISTRY NUMBER :
1198-77-2
LAST UPDATED :
199701
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C5-H3-N4-O3.Na
MOLECULAR WEIGHT :
190.11
WISWESSER LINE NOTATION :
T56 BMVM FMVMVJ &-NA-
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
DOSE :
300 mg/kg
SEX/DURATION :
female 8-10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 6,289,1976 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7188 No. of Facilities: 25 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 1358 (estimated) No. of Female Employees: 956 (estimated)
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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Synonyms
Harnsaeure,Natrium-Salz
uric acid,sodium-salt
1H-Purine-2,6,8(3H)-trione, 7,9-dihydro-, sodium salt (1:1)
