Introduction：Basic information about CAS 957-75-5|5-Bromouridine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 5-Bromouridine |
|---|
| CAS Number | 957-75-5 | Molecular Weight | 323.10 |
|---|
| Density | 2.0±0.1 g/cm3 | Boiling Point | / |
|---|
| Molecular Formula | C9H11BrN2O6 | Melting Point | 180-182 °C (dec.)(lit.) |
|---|
| MSDS | / | Flash Point | / |
|---|
Names
| Name | 5-bromouridine |
|---|
| Synonym | More Synonyms |
|---|
5-Bromouridine BiologicalActivity
| Description | 5-Bromouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. |
|---|
| Related Catalog | Research Areas >>CancerSignaling Pathways >>Cell Cycle/DNA Damage >>Nucleoside Antimetabolite/Analog |
|---|
| References | [1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. |
|---|
Chemical & Physical Properties
| Density | 2.0±0.1 g/cm3 |
|---|
| Melting Point | 180-182 °C (dec.)(lit.) |
|---|
| Molecular Formula | C9H11BrN2O6 |
|---|
| Molecular Weight | 323.10 |
|---|
| Exact Mass | 321.980042 |
|---|
| PSA | 124.78000 |
|---|
| LogP | -0.92 |
|---|
| Index of Refraction | 1.691 |
|---|
| InChIKey | AGFIRQJZCNVMCW-UAKXSSHOSA-N |
|---|
| SMILES | O=c1[nH]c(=O)n(C2OC(CO)C(O)C2O)cc1Br |
|---|
Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- YU7300000
- CHEMICAL NAME :
- Uridine, 5-bromo-
- CAS REGISTRY NUMBER :
- 957-75-5
- BEILSTEIN REFERENCE NO. :
- 0033664
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C9-H11-Br-N2-O6
- MOLECULAR WEIGHT :
- 323.13
- WISWESSER LINE NOTATION :
- T6NVMVJ EE A- BT5OTJ CQ DQ E1Q
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 20 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 43,205,1980
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- >50 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 43,205,1980
|
Safety Information
| Hazard Codes | Xn |
|---|
| Safety Phrases | S22-S24/25 |
|---|
| WGK Germany | 3 |
|---|
| RTECS | YU7300000 |
|---|
Synonyms
| 5-bromo-uridin |
| 5-Br-rU |
| Uridine, 5-bromo- |
| EINECS 213-486-6 |
| 5-Bromouracil ribonucleoside |
| bromouridine |
| 5-BrU |
| 5'-BROMOURIDINE |
| 5-Bromouracil-1-β-D-ribofuranoside |
| 5-Bromouridine |
| 5-BROMO-URIDINE(5-BRU) |
| 5-bromo-UMP |
| MFCD00006528 |
| 1-β-ribofuranosyl-5-bromo-uracil |
| 5-Bromo-D-uridine |
