Introduction：Basic information about CAS 147396-10-9|Endotoxin Inhibitor, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Endotoxin Inhibitor |
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| CAS Number | 147396-10-9 | Molecular Weight | 1224.58000 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C55H97N15O12S2 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | h-lys-thr-lys-cys-lys-phe-leu-lys-lys-cys-oh |
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| Synonym | More Synonyms |
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Endotoxin Inhibitor BiologicalActivity
| Description | Endotoxin inhibitor a synthetic peptide that binds lipid A with high affinity, thereby detoxifying LPS (HY-D1056) and preventing LPS-induced cytokine release in vivo. Endotoxin inhibitor inhibits the febrile response to LPS with very low toxicity and lethality[1]. |
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| Related Catalog | Research Areas >>InfectionSignaling Pathways >>Others >>Others |
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| In Vivo | Endotoxin inhibitor (i.p., 0.5 mg/kg) 可以显著减弱热暴露引起的 IL-1β、COX-2、IκB-β 和 LPS 活性的 mRNA 增加，以及在老年大鼠中热暴露引起的低体温和血浆 ACTH 和儿茶酚胺反应作用[1]。 |
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| References | [1]. Toshihiko Katafuchi, et al. Endotoxin inhibitor blocks heat exposure-induced expression of brain cytokine mRNA in aged rats. Brain Res Mol Brain Res. 2003 Oct 21;118(1-2):24-32. |
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Chemical & Physical Properties
| Molecular Formula | C55H97N15O12S2 |
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| Molecular Weight | 1224.58000 |
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| Exact Mass | 1223.69000 |
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| PSA | 526.15000 |
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| LogP | 4.81840 |
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| InChIKey | ZMJQAGFRHOLBKF-IYXJEWLDSA-N |
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| SMILES | CC(C)CC1NC(=O)C(Cc2ccccc2)NC(=O)C(CCCCN)NC(=O)C(NC(=O)C(CCCCN)NC(=O)C(NC(=O)C(N)CCCCN)C(C)O)CSSCC(C(=O)O)NC(=O)C(CCCCN)NC(=O)C(CCCCN)NC1=O |
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Synonyms
| k-t-k-c-k-f-l-k-k-c |
| lys-thr-lys-cys-lys-phe-leu-lys-lys-cys |
| endotoxin inhibitor |
