Introduction：Basic information about CAS 26690-80-2|Boc-NH-PEG1-OH, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Boc-NH-PEG1-OH |
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| CAS Number | 26690-80-2 | Molecular Weight | 161.199 |
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| Density | 1.0±0.1 g/cm3 | Boiling Point | 267.2±23.0 °C at 760 mmHg |
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| Molecular Formula | C7H15NO3 | Melting Point | / |
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| MSDS | ChineseUSA | Flash Point | 115.4±22.6 °C |
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| Symbol |
GHS05, GHS06 | Signal Word | Danger |
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Names
| Name | tert-butyl n-(2-hydroxyethyl)carbamate |
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| Synonym | More Synonyms |
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Boc-NH-PEG1-OH BiologicalActivity
| Description | Boc-NH-PEG1-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>PROTAC >>PROTAC Linker |
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| Target | PEGs |
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| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
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| References | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
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Chemical & Physical Properties
| Density | 1.0±0.1 g/cm3 |
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| Boiling Point | 267.2±23.0 °C at 760 mmHg |
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| Molecular Formula | C7H15NO3 |
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| Molecular Weight | 161.199 |
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| Flash Point | 115.4±22.6 °C |
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| Exact Mass | 161.105194 |
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| PSA | 58.56000 |
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| LogP | 0.49 |
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| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
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| Index of Refraction | 1.450 |
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| InChIKey | GPTXCAZYUMDUMN-UHFFFAOYSA-N |
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| SMILES | CC(C)(C)OC(=O)NCCO |
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| Storage condition | 2-8°C |
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Safety Information
| Symbol |
GHS05, GHS06 |
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| Signal Word | Danger |
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| Hazard Statements | H301-H315-H318-H335 |
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| Precautionary Statements | P261-P280-P301 + P310-P305 + P351 + P338 |
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| Personal Protective Equipment | Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter |
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| Hazard Codes | T:Toxic; |
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| Risk Phrases | R25;R37/38;R41 |
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| Safety Phrases | S26-S39-S45-S36/37/39 |
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| RIDADR | UN 2810 6.1/PG 3 |
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| WGK Germany | 3 |
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| Hazard Class | 6.1 |
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| HS Code | 2924199090 |
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Customs
| HS Code | 2924199090 |
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| Summary | 2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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Articles2
More Articles
Synthesis , 133, (1993)
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Synth. Commun. 21 , 359, (1991)
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Synonyms
| tert-Butyl (2-hydroxyethyl)carbamate |
| (2-hydroxyethyl)carbamic acid t-butyl ester |
| Boc-NH-(CH2)2-1-naphthylamide |
| boc-ethanolamine |
| Boc-2-aminoethanol |
| 2-Boc-ethanolamine |
| 2-(tert-Butoxycarbonyl)ethanolamine |
| 2-(tert-ButoxycarbonylaMino)-1-ethanol |
| (2-hydroxy-ethyl)-carbamic acid tert-butyl ester |
| Carbamic acid, N-(2-hydroxyethyl)-, 1,1-dimethylethyl ester |
| MFCD00056657 |
| N-(t-butoxycarbonyl)-2-hydroxy-ethylamine |
| N-(tert-Butoxycarbonyl)ethanolamine |
| 2-(Boc-amino)-1-ethanol |
| N-(2-Hydroxyethyl)carbamic Acid tert-Butyl Ester |
| boc-aminoethanol |
| Boc-Gly-ol |
| Boc-glycinol |
| 2-Methyl-2-propanyl (2-hydroxyethyl)carbamate |
| N-Boc-ethanolamine |
| tert-Butyl N-(2-Hydroxyethyl)carbamate |
| 2-(tert-butoxycarbonylamino)ethanol |
| tert-butyl N-(2-hydroxyethyl)-carbamate |
