Introduction：Basic information about CAS 915363-56-3|Cot inhibitor-2, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Cot inhibitor-2 |
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| CAS Number | 915363-56-3 | Molecular Weight | 539.43500 |
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| Density | 1.45 | Boiling Point | 713.3ºC at 760 mmHg |
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| Molecular Formula | C26H25Cl2FN8 | Melting Point | / |
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| MSDS | / | Flash Point | 385.2ºC |
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Names
| Name | 8-chloro-4-(3-chloro-4-fluoroanilino)-6-[[1-(1-ethylpiperidin-4-yl)triazol-4-yl]methylamino]quinoline-3-carbonitrile |
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| Synonym | More Synonyms |
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Cot inhibitor-2 BiologicalActivity
| Description | Cot inhibitor-2 is a COT/Tpl2 inhibitor. |
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| Related Catalog | Signaling Pathways >>Apoptosis >>TNF ReceptorResearch Areas >>Cancer |
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| References | [1]. Wu, Junjun et al Selective inhibitors of tumor progression loci-2 (Tpl2) kinase with potent inhibition of TNF-production in human whole blood. Bioorganic & Medicinal Chemistry Letters (2009), 19(13), 3485-3488. |
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Chemical & Physical Properties
| Density | 1.45 |
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| Boiling Point | 713.3ºC at 760 mmHg |
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| Molecular Formula | C26H25Cl2FN8 |
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| Molecular Weight | 539.43500 |
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| Flash Point | 385.2ºC |
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| Exact Mass | 538.15600 |
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| PSA | 94.69000 |
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| LogP | 6.24028 |
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| Index of Refraction | 1.702 |
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| InChIKey | PHNZIIMWDVXPGG-UHFFFAOYSA-N |
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| SMILES | CCN1CCC(n2cc(CNc3cc(Cl)c4ncc(C#N)c(Nc5ccc(F)c(Cl)c5)c4c3)nn2)CC1 |
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Synonyms
| substituted 6-aminoquinoline-3-carbonitrile,34 |
| 8-CHLORO-4-[(3-CHLORO-4-FLUOROPHENYL)AMINO]-6-[[[1-(1-ETHYLPIPERIDIN-4-YL)-1H-1,2,3-TRIAZOL-4-YL]METHYL]AMINO]QUINOLINE-3-CARBONITRILE |
| Cot inhibitor-2 |
