CAS 116-43-8|succinylsulfathiazole
Introduction：Basic information about CAS 116-43-8|succinylsulfathiazole, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | succinylsulfathiazole | ||
|---|---|---|---|
| CAS Number | 116-43-8 | Molecular Weight | 355.389 |
| Density | 1.6±0.1 g/cm3 | Boiling Point | / |
| Molecular Formula | C13H13N3O5S2 | Melting Point | 187 - 193ºC |
| MSDS | ChineseUSA | Flash Point | / |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | 4'-(2-Thiazolylsulfamoyl)succinanilic acid |
|---|---|
| Synonym | More Synonyms |
succinylsulfathiazole BiologicalActivity
| Description | Succinylsulfathiazole is a sulfonamide, it is an ultra long acting drug. |
|---|---|
| Related Catalog | Signaling Pathways >>Anti-infection >>BacterialResearch Areas >>Infection |
Chemical & Physical Properties
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Melting Point | 187 - 193ºC |
| Molecular Formula | C13H13N3O5S2 |
| Molecular Weight | 355.389 |
| Exact Mass | 355.029663 |
| PSA | 162.08000 |
| LogP | 0.68 |
| Index of Refraction | 1.679 |
| InChIKey | SKVLYVHULOWXTD-UHFFFAOYSA-N |
| SMILES | O=C(O)CCC(=O)Nc1ccc(S(=O)(=O)Nc2nccs2)cc1 |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 5700 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 75,231,1942
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 10 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 7,151,1981 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81640 No. of Facilities: 58 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 230 (estimated)
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H317 |
| Precautionary Statements | P280 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Faceshields;Gloves |
| Hazard Codes | Xn:Harmful; |
| Risk Phrases | R42/43 |
| Safety Phrases | S22-S36/37-S45 |
| RIDADR | 3249 |
| WGK Germany | 3 |
| RTECS | WM4767000 |
| Packaging Group | III |
| Hazard Class | 6.1(b) |
| HS Code | 2935009090 |
Customs
| HS Code | 2935009090 |
|---|---|
| Summary | 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0% |
Articles30
More Articles| Arsenic urinary speciation in Mthfr deficient mice injected with sodium arsenate. Toxicol. Lett. 215(3) , 214-8, (2012) In most mammalian species, arsenic biotransformation occurs primarily by biomethylation and reduction reactions, with dimethylarsinic acid being the predominant metabolite excreted in the urine. Methy... | |
| Prediction of drug intestinal absorption by new linear and non-linear QSPR. Eur. J. Med. Chem. 46 , 218-28, (2011) In order to minimize the high attrition rate that usually characterizes drug research and development projects, current medicinal chemists aim to characterize both pharmacological and ADME profiles at... | |
| Folate deficiency induces neurodegeneration and brain dysfunction in mice lacking uracil DNA glycosylase. J. Neurosci. 28 , 7219-7230, (2008) Folate deficiency and resultant increased homocysteine levels have been linked experimentally and epidemiologically with neurodegenerative conditions like stroke and dementia. Moreover, folate deficie... |
Synonyms
| EINECS 204-141-0 |
| Succinanilic acid, 4'-(2-thiazolylsulfamoyl)- |
| MFCD00022437 |
| succinylsulfathiazole |
| 4-(Succinylamino)-N-(2-thiazolyl)benzenesulfonamide Hydrate |
| Succinylsulfathiazole Hydrate |
| Butanoic acid, 4-oxo-4-[[4-[(2-thiazolylamino)sulfonyl]phenyl]amino]- |
| 4-(Succinylamino)-N-(2-thiazolyl)benzenesulfonamide |
| N1-(2-THIAZOLYL)-N4-SUCCINOYLSULFANILAMIDE |
| N4-Succinyl-N-(2-thiazolyl)sulfanilamide Hydrate |
| N4-Succinyl-N-(2-thiazolyl)sulfanilamide |
| 4-oxo-4-[4-(1,3-thiazol-2-ylsulfamoyl)anilino]butanoic acid |
| p-2-Thiazolylsulfamoylsuccinanilic acid |
| 4-Oxo-4-{[4-(1,3-thiazol-2-ylsulfamoyl)phenyl]amino}butanoic acid |
| 4-oxo-4-{4-[(1,3-thiazol-2-ylamino)sulfonyl]anilino}butanoic acid |
