CAS 152946-68-4|Nolatrexed dihydrochloride

Introduction：Basic information about CAS 152946-68-4|Nolatrexed dihydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Nolatrexed dihydrochloride BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Nolatrexed dihydrochloride
CAS Number	152946-68-4	Molecular Weight	357.258
Density	/	Boiling Point	493.6ºCat 760 mmHg
Molecular Formula	C₁₄H₁₄Cl₂N₄OS	Melting Point	301-302ºC
MSDS	/	Flash Point	252.3ºC

Names

Name	2-amino-6-methyl-5-pyridin-4-ylsulfanyl-1H-quinazolin-4-one,dihydrochloride
Synonym	More Synonyms

Nolatrexed dihydrochloride BiologicalActivity

Description	Nolatrexed dihydrochloride (AG 337) is a non-competitive lipophilic inhibitor of thymidylate synthase, interacts at the folate cofactor binding site of the enzyme, with a Ki of 11 nM for human thymidylate synthase[1]. Nolatrexed dihydrochloride (AG 337) has anti-cancer activity, induces cell cycle arrest in S phase of cancer cells[2].
Related Catalog	Signaling Pathways >>Apoptosis >>Thymidylate SynthaseResearch Areas >>Cancer
Target	Ki: 11 nM (Human Thymidylate Synthase)[1]
References	[1]. Webber S, et al. AG337, a novel lipophilic thymidylate synthase inhibitor: in vitro and in vivo preclinical studies. Cancer Chemother Pharmacol. 1996;37(6):509-17. [2]. McGuire JJ, et al. Characterization of the effect of AG337, a novel lipophilic thymidylate synthase inhibitor, on human head and neck and human leukemia cell lines.

Chemical & Physical Properties

Boiling Point	493.6ºCat 760 mmHg
Melting Point	301-302ºC
Molecular Formula	C₁₄H₁₄Cl₂N₄OS
Molecular Weight	357.258
Flash Point	252.3ºC
Exact Mass	356.026550
PSA	109.96000
LogP	4.54510
Storage condition	Hygroscopic, -20°C Freezer, Under Inert Atmosphere
Stability	Hygroscopic

Synonyms

2-Amino-6-methyl-5-(4-pyridinylsulfanyl)-4(1H)-quinazolinone dihydrochloride

Thymitaq

2-Amino-6-methyl-5-(pyridin-4-ylsulfanyl)quinazolin-4(3H)-one dihydrochloride

MFCD00917041

4(1H)-Quinazolinone, 2-amino-6-methyl-5-(4-pyridinylthio)-, hydrochloride (1:2)

Nolatrexed dihydrochloride

AG 337

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