Introduction：Basic information about CAS 85320-68-9|Amosulalol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Amosulalol |
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| CAS Number | 85320-68-9 | Molecular Weight | 380.45900 |
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| Density | 1.268g/cm3 | Boiling Point | 608.7ºC at 760mmHg |
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| Molecular Formula | C18H24N2O5S | Melting Point | / |
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| MSDS | / | Flash Point | 321.9ºC |
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Names
| Name | 5-[1-hydroxy-2-[2-(2-methoxyphenoxy)ethylamino]ethyl]-2-methylbenzenesulfonamide |
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| Synonym | More Synonyms |
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Amosulalol BiologicalActivity
| Description | Amosulalol (YM 09538) is an orally active and dual inhibitor of α1/β1-Adrenergic Receptor. Amosulalol exhibits antihypertensive activity via α1-Adrenergic Receptor inhibition. Amosulalol decreases reflexogenic increases in heart rate and plasma renin activity (PRA) via β1-Adrenergic Receptor inhibition in spontaneously hypertensive rats (SHR)[1]. |
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| Related Catalog | Research Areas >>Cardiovascular DiseaseSignaling Pathways >>GPCR/G Protein >>Adrenergic Receptor |
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| Target | α1-adrenergic receptor Beta-1 adrenergic receptor |
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| In Vivo | Amosulalol (3-30 mg/kg; 口服; 单剂量) 降低高血压大鼠的急性收缩压[1]。 Amosulalol (50 mg/kg; 口服; 每天 2 次, 共 12 周) 产生不耐受的降压作用，还降低高血压大鼠模型中心率和血浆肾素活性 (PRA) 增加[1]。 |
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| References | [1]. Honda K, et al. Autonomic and antihypertensive activity of oral amosulalol (YM-09538), a combined alpha- and beta-adrenoceptor blocking agent in conscious rats. Jpn J Pharmacol. 1985 May;38(1):31-41. |
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Chemical & Physical Properties
| Density | 1.268g/cm3 |
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| Boiling Point | 608.7ºC at 760mmHg |
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| Molecular Formula | C18H24N2O5S |
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| Molecular Weight | 380.45900 |
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| Flash Point | 321.9ºC |
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| Exact Mass | 380.14100 |
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| PSA | 119.26000 |
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| LogP | 3.52500 |
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| InChIKey | LVEXHFZHOIWIIP-UHFFFAOYSA-N |
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| SMILES | COc1ccccc1OCCNCC(O)c1ccc(C)c(S(N)(=O)=O)c1 |
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Synonyms
| Amosulalolum [Latin] |
| 5-[1-hydroxy-2-[2-(2-methoxyphenoxyl)ethylamino]ethyl]-2-methylbenzenesulfonamide |
| (+-)-5-(1-Hydroxy-2-((2-(o-methoxyphenoxy)ethyl)amino)ethyl)-o-toluenesulfonamide |
| Amosulalolum |
| Lowgan |
| Amosulalol |
| (+/-)-5-[1-hydroxy-2-[[2-(2-methoxyphenoxy)ethyl]amino]ethyl]-2-methylbenzenesulfonamide |
| Amosulalol [INN] |
