CAS 192374-14-4|(S,S)-Hydroxy Bupropion

Introduction：Basic information about CAS 192374-14-4|(S,S)-Hydroxy Bupropion, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. (S,S)-Hydroxy Bupropion BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	(S,S)-Hydroxy Bupropion
CAS Number	192374-14-4	Molecular Weight	255.74
Density	1.144g/cm3	Boiling Point	386.574ºC at 760 mmHg
Molecular Formula	C₁₃H₁₈ClNO₂	Melting Point	/
MSDS	/	Flash Point	187.594ºC

Names

Name	(2S,3S)-2-(3-chlorophenyl)-3,5,5-trimethylmorpholin-2-ol
Synonym	More Synonyms

(S,S)-Hydroxy Bupropion BiologicalActivity

Description	Radafaxine ((S,S)-Hydroxybupropion) is an antidepressant. Radafaxine blocks dopamine transporters (DAT). Radafaxine is an active metabolite of Bupropion[1][2].
Related Catalog	Research Areas >>Neurological DiseaseSignaling Pathways >>Membrane Transporter/Ion Channel >>Monoamine Transporter
References	[1]. Volkow ND, et al. The slow and long-lasting blockade of dopamine transporters in human brain induced by the new antidepressant drug radafaxine predict poor reinforcing effects. Biol Psychiatry. 2005 Mar 15;57(6):640-6. [2]. Xu H, et al. Stereoselective analysis of hydroxybupropion and application to drug interaction studies. Chirality. 2007 Mar;19(3):163-70.

Description

Radafaxine ((S,S)-Hydroxybupropion) is an antidepressant. Radafaxine blocks dopamine transporters (DAT). Radafaxine is an active metabolite of Bupropion[1][2].

Related Catalog

Research Areas >>Neurological DiseaseSignaling Pathways >>Membrane Transporter/Ion Channel >>Monoamine Transporter

References

[1]. Volkow ND, et al. The slow and long-lasting blockade of dopamine transporters in human brain induced by the new antidepressant drug radafaxine predict poor reinforcing effects. Biol Psychiatry. 2005 Mar 15;57(6):640-6.

[2]. Xu H, et al. Stereoselective analysis of hydroxybupropion and application to drug interaction studies. Chirality. 2007 Mar;19(3):163-70.

Chemical & Physical Properties

Density	1.144g/cm3
Boiling Point	386.574ºC at 760 mmHg
Molecular Formula	C₁₃H₁₈ClNO₂
Molecular Weight	255.74
Flash Point	187.594ºC
Exact Mass	291.079285
PSA	41.49000
LogP	3.40280
Vapour Pressure	0mmHg at 25°C
Index of Refraction	1.523
InChIKey	RCOBKSKAZMVBHT-TVQRCGJNSA-N
SMILES	CC1NC(C)(C)COC1(O)c1cccc(Cl)c1

Synonyms

(S,S)-2-(3'-chlorophenyl)-3,5,5-trimethylmorpholine-2-ol

Radafaxine hydrochloride

(2S,3S)-2-(3-Chlorophenyl)-3,5,5-trimethyl-2-morpholinol hydrochloride (1:1)

(2S,3S)-hydroxybupropion

(RS,RS)-Hydroxybupropion

Radafaxine [INN]

(2S,3S)-2-Hydroxy-2-(3'-chlorophenyl)-3,5,5-trimethylmorpholine

(+)-(2S,3S)-2-(3-chlorophenyl)-3,5,5-trimethyl-2-morpholinol

2-Morpholinol, 2-(3-chlorophenyl)-3,5,5-trimethyl-, (2S,3S)-, hydrochloride (1:1)

Radafaxine

(S,S)-Hydroxybupropion

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