CAS 992-78-9|ubiquinol-10
Introduction：Basic information about CAS 992-78-9|ubiquinol-10, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | ubiquinol-10 | ||
|---|---|---|---|
| CAS Number | 992-78-9 | Molecular Weight | 865.359 |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 866.9±65.0 °C at 760 mmHg |
| Molecular Formula | C59H92O4 | Melting Point | 48-49ºC |
| MSDS | / | Flash Point | 478.1±34.3 °C |
Names
| Name | Ubiquinol,Dihydrocoenzyme Q10 |
|---|---|
| Synonym | More Synonyms |
ubiquinol-10 BiologicalActivity
| Description | Ubiquinol (Ubiquinol-10) is a reduced form of coenzyme Q10 (CoQ10). Ubiquinol is a potent antioxidant that has the capacity to protect Vitamin E, and also helps to regenerate depleted vitamin E and Vitamin C. Ubiquinol is both lipophilic and hydrophilic and acts as transmembrane factor preventing lipid peroxidation and propagation by transferring electrons to ROS[1][2][3]. |
|---|---|
| Related Catalog | Research Areas >>Others |
| In Vitro | The lipophilic environment encircles the lipophilic low-molecular-weight antioxidants (α-tocopherol, β-carotene, and Ubiquinol) and prevents them from reacting as skin protectors[1]. Oxidative stress is defined as a disturbance in the prooxidant-antioxidant balance in favor of the former and has been suggested to be a relevant factor in aging as well as in different pathological conditions, such as heart attack, diabetes, and cancer. Ubiquinol is very sensitive against oxygen radicals and gives ubiquinone as an oxidation product. Therefore, the ratio of ubiquinol to ubiquinone should be a good marker of oxidative stress because of its definition[2]. |
| In Vivo | The oxidized (UQox) and reduced (Ubiquinol) forms of ubiquinone (UQ) homologues in rat tissues and subcellular fractionsare analyzed. The levels of these homologues are highest in heart with lesser amounts occurring in kidney, liver and other organs. In liver and blood plasma, the UQred homologue amounted to 70-80% of the total UQ (UQox + Ubiquinol = t-UQ). Ubiquinol is less than 30% of t-UQ in other tissues and blood cells. t-UQ is much higher in leukocytes and platelets in blood than in erythrocytes. In erythrocytes, t-UQ is exclusively located in the cell membranes.Ubiquinol is also found in all subcellular fractions isolated from liver and kidney in about the same ratio as Ubiquinol/t-UQ is present in the whole organ. The levels of Ubiquinol per mg protein in subcellular fractions from liver is highest in mitochondria, with lesser amounts present in plasma membranes, lysosomes, Golgi complex, nuclei, microsomes and cytosol. In the mitochondria, the outer membranes are richer in t-UQ than the inner membranes[4]. |
| References | [1]. Grammenandi K, et al. Low-Molecular-Weight Hydrophilic and Lipophilic Antioxidants in Nonmelanoma Skin Carcinomas and Adjacent Normal-Looking Skin. Skin Pharmacol Physiol. 2016;29(6):324-331. [2]. Yamamoto Y, et al. Plasma ratio of ubiquinol and ubiquinone as a marker of oxidative stress. Mol Aspects Med. 1997;18 Suppl:S79-84. [3]. Zhang Y, et al. Ubiquinol is superior to ubiquinone to enhance Coenzyme Q10 status in older men. Food Funct. 2018 Nov 14;9(11):5653-5659. [4]. Takahashi T, et al. Distribution of ubiquinone and ubiquinol homologues in rat tissues and subcellular fractions. Lipids. 1993 Sep;28(9):803-9. |
Chemical & Physical Properties
| Density | 1.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 866.9±65.0 °C at 760 mmHg |
| Melting Point | 48-49ºC |
| Molecular Formula | C59H92O4 |
| Molecular Weight | 865.359 |
| Flash Point | 478.1±34.3 °C |
| Exact Mass | 864.699585 |
| PSA | 58.92000 |
| LogP | 21.06 |
| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
| Index of Refraction | 1.526 |
| InChIKey | QNTNKSLOFHEFPK-UPTCCGCDSA-N |
| SMILES | COc1c(O)c(C)c(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)c(O)c1OC |
Safety Information
| RIDADR | NONH for all modes of transport |
|---|
Articles1
More Articles| Topical treatment with coenzyme Q10-containing formulas improves skin's Q10 level and provides antioxidative effects. Biofactors 41 , 383-90, (2016) Ubiquinone (coenzyme Q10, Q10) represents an endogenously synthesized lipid-soluble antioxidant which is crucial for cellular energy production but is diminished with age and under the influence of ex... |
Synonyms
| ubiquinol Q10 |
| ubiquinol-10 |
| 2-[(2E,6E,10E,14E,18E,22E,26E,30E,34E)-3,7,11,15,19,23,27,31,35,39-DecaMethyl -2,6,10,14,18 |
| 1-((2E,6E,10E,14E,18E,22E,26E,30E,34E)-3,7,11,15,19,23,27,31,35,39-decamethyltetraconta-2,6,10,14,18,22,26,30,34,38-decaenyl)-5,6-dimethoxy-3-methylbenzene-1,4-diol |
| 2-[(2E,6E,10E,14E,18E,22E,26E,30E,34E)-3,7,11,15,19,23,27,31,35,39-Decamethyl-2,6,10,14,18,22,26,30,34,38-tetracontadecenyl]-5,6-dimethoxy-3-methylbenzene-1,4-diol |
| Reduced Coenzyme Q10 |
| 2-[(2E,6E,10E,14E,18E,22E,26E,30E,34E)-3,7,11,15,19,23,27,31,35,39-Decamethyl-2,6,10,14,18,22,26,30,34,38-tetracontadecaen-1-yl]-5,6-dimethoxy-3-methyl-1,4-benzenediol |
| 1,4-Benzenediol, 2-[(2E,6E,10E,14E,18E,22E,26E,30E,34E)-3,7,11,15,19,23,27,31,35,39-decamethyl-2,6,10,14,18,22,26,30,34,38-tetracontadecaen-1-yl]-5,6-dimethoxy-3-methyl- |
| Ubiquinol 50 |
| UBIQUINOL (Reduced coenzyme Q10) |
| Reduced Ubiquinone Q10 |
| 2-[(2E,6E,10E,14E,18E,22E,26E,30E,34E)-3,7,11,15,19,23,27,31,35,39-Decamethyl-2,6,10,14,18,22,26,30,34,38-tetracontadecenyl]-5,6-dimethoxy-3-methylhydroquinone |
| Dihydrocoenzyme Q10 |
| Reduced ubiquinone-10 |
| coenzyme Q10-H2 |
