CAS 113963-68-1|n-methylbis(indol-3-yl)maleimide

Introduction：Basic information about CAS 113963-68-1|n-methylbis(indol-3-yl)maleimide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. n-methylbis(indol-3-yl)maleimide BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Customs
6. Synonyms

Common Name	n-methylbis(indol-3-yl)maleimide
CAS Number	113963-68-1	Molecular Weight	341.363
Density	1.5±0.1 g/cm3	Boiling Point	655.7±55.0 °C at 760 mmHg
Molecular Formula	C₂₁H₁₅N₃O₂	Melting Point	271°C
MSDS	/	Flash Point	350.3±31.5 °C

Names

Name	3,4-bis(1H-indol-3-yl)-1-methylpyrrole-2,5-dione
Synonym	More Synonyms

n-methylbis(indol-3-yl)maleimide BiologicalActivity

Description	Bisindolylmaleimide V is a cell-permeable negative control for protein kinase C inhibition studies with an IC50 value over 100 µM[1]. Bisindolylmaleimide V blocks the activation of mitogen-stimulated protein kinase p70s6k/p85s6k (S6K) in vivo with an IC50 of 8 µM[2].
Related Catalog	Research Areas >>CancerSignaling Pathways >>MAPK/ERK Pathway >>Ribosomal S6 Kinase (RSK)
References	[1]. Lazareno S, et al. Muscarinic interactions of bisindolylmaleimide analogues. Eur J Pharmacol. 1998 Nov 6;360(2-3):281-4. [2]. Marmy-Conus N, et al. Ro 31-6045, the inactive analogue of the protein kinase C inhibitor Ro 31-8220, blocks in vivo activation of p70(s6k)/p85(s6k): implications for the analysis of S6K signalling. FEBS Lett. 2002 May 22;519(1-3):135-40.

Description

Bisindolylmaleimide V is a cell-permeable negative control for protein kinase C inhibition studies with an IC50 value over 100 µM[1]. Bisindolylmaleimide V blocks the activation of mitogen-stimulated protein kinase p70s6k/p85s6k (S6K) in vivo with an IC50 of 8 µM[2].

Related Catalog

Research Areas >>CancerSignaling Pathways >>MAPK/ERK Pathway >>Ribosomal S6 Kinase (RSK)

References

[1]. Lazareno S, et al. Muscarinic interactions of bisindolylmaleimide analogues. Eur J Pharmacol. 1998 Nov 6;360(2-3):281-4.

[2]. Marmy-Conus N, et al. Ro 31-6045, the inactive analogue of the protein kinase C inhibitor Ro 31-8220, blocks in vivo activation of p70(s6k)/p85(s6k): implications for the analysis of S6K signalling. FEBS Lett. 2002 May 22;519(1-3):135-40.

Chemical & Physical Properties

Density	1.5±0.1 g/cm3
Boiling Point	655.7±55.0 °C at 760 mmHg
Melting Point	271°C
Molecular Formula	C₂₁H₁₅N₃O₂
Molecular Weight	341.363
Flash Point	350.3±31.5 °C
Exact Mass	341.116425
PSA	68.96000
LogP	3.65
Vapour Pressure	0.0±2.0 mmHg at 25°C
Index of Refraction	1.794
InChIKey	SWAWYMIKGOHZMR-UHFFFAOYSA-N
SMILES	CN1C(=O)C(c2c[nH]c3ccccc23)=C(c2c[nH]c3ccccc23)C1=O
Storage condition	−20°C
Water Solubility	DMSO: soluble

Safety Information

Hazard Codes	Xi
WGK Germany	3
HS Code	2933990090

Customs

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Synonyms

Ro 31-6045

2,3-bis(1H-Indol-3-yl)-N-methylmaleimide

MFCD00236433

3,4-Di(1H-indol-3-yl)-1-methyl-1H-pyrrole-2,5-dione

bisindolylmaleimide v

3,4-bis(3-indolyl)-1-methyl-pyrrole-2,5-dione

1-Methyl-3,4-bis(3-indolyl)maleimide

1H-Pyrrole-2,5-dione,3,4-di-1H-indol-3-yl-1-methyl

1H-Pyrrole-2,5-dione, 3,4-di-1H-indol-3-yl-1-methyl-

n-methylbis(indol-3-yl)maleimide

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