Introduction：Basic information about CAS 68377-92-4|5-(2-((3-(tert-Butylamino)-2-hydroxypropyl)thio)thiazol-4-yl)thiophene-2-carbo, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 5-(2-((3-(tert-Butylamino)-2-hydroxypropyl)thio)thiazol-4-yl)thiophene-2-carboxamide |
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| CAS Number | 68377-92-4 | Molecular Weight | 371.541 |
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| Density | 1.4±0.1 g/cm3 | Boiling Point | 599.8±60.0 °C at 760 mmHg |
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| Molecular Formula | C15H21N3O2S3 | Melting Point | 148-149ºC |
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| MSDS | / | Flash Point | 316.6±32.9 °C |
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Names
| Name | 5-[2-[3-(tert-butylamino)-2-hydroxypropyl]sulfanyl-1,3-thiazol-4-yl]thiophene-2-carboxamide |
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| Synonym | More Synonyms |
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BiologicalActivity
| Description | Arotinolol is a nonselective α/β-adrenergic receptor blocker and a vasodilating β-blocker. Arotinolol is an antihypertensive agent for the treatment of a variety of cardiovascular pathologies as well as non-cardiovascular diseases[1]. |
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| Related Catalog | Research Areas >>Cardiovascular DiseaseSignaling Pathways >>GPCR/G Protein >>Adenosine Receptor |
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| Target | IC50: α/β-adrenergic receptor |
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| In Vivo | Arotinolol (oral gavage; 200 mg/kg; 8 weeks) can significantly decrease central arterial pressure (CAP) and pulse wave velocity (PWV), in addition, it reduces aortic collagen depositions and finally improves arterial stiffness in SHR mouse[1]. Animal Model: SHR mice[1] Dosage: 200 mg/kg Administration: Orally gavage; 200 mg/kg; once daily; 8 weeks Result: Improved arterial stiffness in SHR. |
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| References | [1]. Zhou W, et al. Mechanisms of improved aortic stiffness by arotinolol in spontaneously hypertensive rats.PLoS One. 2014 Feb 12;9(2):e88722. |
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Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
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| Boiling Point | 599.8±60.0 °C at 760 mmHg |
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| Melting Point | 148-149ºC |
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| Molecular Formula | C15H21N3O2S3 |
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| Molecular Weight | 371.541 |
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| Flash Point | 316.6±32.9 °C |
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| Exact Mass | 371.079590 |
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| PSA | 170.02000 |
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| LogP | 2.67 |
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| Vapour Pressure | 0.0±1.8 mmHg at 25°C |
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| Index of Refraction | 1.646 |
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| InChIKey | BHIAIPWSVYSKJS-UHFFFAOYSA-N |
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| SMILES | CC(C)(C)NCC(O)CSc1nc(-c2ccc(C(N)=O)s2)cs1 |
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| Storage condition | 2-8°C |
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Safety Information
Synonyms
| Arotinolo |
| 5-(2-{[3-(tert-Butylamino)-2-hydroxypropyl]sulfanyl}-1,3-thiazol-4-yl)thiophene-2-carboxamide |
| 5-[2-({2-Hydroxy-3-[(2-methyl-2-propanyl)amino]propyl}sulfanyl)-1,3-thiazol-4-yl]-2-thiophenecarboxamide |
| Arottnolol |
| Arotinolol |
| UNII:394E3P3B99 |
| 2-Thiophenecarboxamide, 5-[2-[[3-[(1,1-dimethylethyl)amino]-2-hydroxypropyl]thio]-4-thiazolyl]- |
| (±)-5-[2-[[3-[(1,1-Dimethylethyl)amino]-2-hydroxypropyl]thio]-4-thiazolyl]-2-thiophenecarboxamide |
| ARL |
| 2-(3'-tert-Butylamino-2'-hydroxypropylthio)-4-(5'-carbamoyl-2'-thienyl)thiazole |
| 5-[2-({3-[(1,1-dimethylethyl)amino]-2-hydroxypropyl}thio)-1,3-thiazol-4-yl]thiophene-2-carboxamide |
