Introduction：Basic information about CAS 19036-73-8|(+)-Norfenfluramine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | (+)-Norfenfluramine |
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| CAS Number | 19036-73-8 | Molecular Weight | 203.20400 |
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| Density | 1.152g/cm3 | Boiling Point | 215.2ºC at 760mmHg |
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| Molecular Formula | C10H12F3N | Melting Point | / |
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| MSDS | / | Flash Point | 88.9ºC |
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Names
| Name | (s)-1-(3-trifluoromethylphenyl)-2-aminopropane |
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| Synonym | More Synonyms |
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(+)-Norfenfluramine BiologicalActivity
| Description | (+)-Norfenfluramine a major hepatic metabolite of (+)-fenfluramine, is a selective 5-HT2B receptor agonist (Ki: 11.2 nM). (+)-Norfenfluramine potently stimulates the hydrolysis of inositol phosphates and increases intracellular Ca2+. (+)-Norfenfluramine can be used for the research of primary pulmonary hypertension and valvular heart disease[1]. |
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| Related Catalog | Research Areas >>Cardiovascular DiseaseSignaling Pathways >>GPCR/G Protein >>5-HT ReceptorSignaling Pathways >>Neuronal Signaling >>5-HT Receptor |
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| Target | 5-HT2B Receptor:11.2 nM (Ki) 5-HT2A Receptor:1516 nM (Ki) 5-HT2C Receptor:324 nM (Ki) |
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| In Vitro | (+)-Norfenfluramine (1 nM to 100 μM) contracts arteries with a dramatic decrease in threshold (aorta and mesenteric resistance artery) in rats[1]. (+)-Norfenfluramine (1 and 10 μM, 3 min) induces contraction in aorta from tissues of normotensive and hypertensive rats[1]. (+)-Norfenfluramine (0-10 μM, 3 min) induces 5-HT release from rat hippocampal synaptosomes by Ca2+-dependent way [2]. |
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| In Vivo | (+)-Norfenfluramine (1-300 μg/kg, i.v.) induces pressor response in conscious SHAM and DOCA-salt rats[1]. (+)-Norfenfluramine (2.5 and 5 mg/kg, i.p.) decreases of 5-HT and 5-HIAA levels in telencephalon and brainstem of rats[3]. Animal Model: Conscious SHAM and DOCA-salt rats[1]. Dosage: 1-300 μg/kg Administration: Intravenous injection (i.v.), given in a cumulative fashion at 6-min intervals. Result: Induced pressor response in conscious SHAM and DOCA-salt rats. (change in mean arterial blood pressure at 300 μg/kg, mm Hg, SHAM vehicle=36, SHAM ketanserin=7, DOCA=51, DOCA ketanserin=19). |
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| References | [1]. Wei Ni, et al. The 5-hydroxytryptamine2A receptor is involved in (+)-norfenfluramine-induced arterial contraction and blood pressure increase in deoxycorticosterone acetate-salt hypertension. J Pharmacol Exp Ther. 2007 May;321(2):485-91. [2]. M Gobbi, et al. In vitro studies on the mechanism by which (+)-norfenfluramine induces serotonin and dopamine release from the vesicular storage pool. Naunyn Schmiedebergs Arch Pharmacol. 1998 Sep;358(3):323-7. [3]. R Invernizzi, et al. Is receptor activation involved in the mechanism by which (+)-fenfluramine and (+)-norfenfluramine deplete 5-hydroxytryptamine in the rat brain? Br J Pharmacol. 1982 Mar;75(3):525-30. |
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Chemical & Physical Properties
| Density | 1.152g/cm3 |
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| Boiling Point | 215.2ºC at 760mmHg |
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| Molecular Formula | C10H12F3N |
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| Molecular Weight | 203.20400 |
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| Flash Point | 88.9ºC |
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| Exact Mass | 203.09200 |
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| PSA | 26.02000 |
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| LogP | 3.29540 |
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| Vapour Pressure | 0.15mmHg at 25°C |
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| Index of Refraction | 1.467 |
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Safety Information
Customs
| HS Code | 2921499090 |
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| Summary | 2921499090 other aromatic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0% |
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Synonyms
| dexnorfenfluramine |
| Dexibuprofen Lysine |
| d-norfenfluramine |
