CAS 198481-32-2|Bazedoxifene

Introduction：Basic information about CAS 198481-32-2|Bazedoxifene, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Bazedoxifene BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Bazedoxifene
CAS Number	198481-32-2	Molecular Weight	470.603
Density	1.2±0.1 g/cm3	Boiling Point	694.4±55.0 °C at 760 mmHg
Molecular Formula	C₃₀H₃₄N₂O₃	Melting Point	/
MSDS	/	Flash Point	373.8±31.5 °C

Names

Name	1-[[4-[2-(azepan-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methylindol-5-ol
Synonym	More Synonyms

Bazedoxifene BiologicalActivity

Description	Bazedoxifene is a selective estrogen receptor modulator (SERM) currently in development for osteoporosis prevention and treatment.IC50 value:Target: estrogen receptor modulatorPreclinical and clinical studies with bazedoxifene demonstrate more tissue selectivity than other SERMs. In particular, bazedoxifene has minimal if any agonist activity in the uterus and is able to antagonize effects of estrogen on the uterus. Animal studies and early clinical studies suggest effects in the bone similar to other SERMs with prevention of postmenopausal bone loss.
Related Catalog	Signaling Pathways >>Others >>Estrogen Receptor/ERRResearch Areas >>Cancer
References	[1]. Lewis-Wambi JS, et al. The selective estrogen receptor modulator bazedoxifene inhibits hormone-independent breast cancer cell growth and down-regulates estrogen receptor α and cyclin D1. Mol Pharmacol. 2011 Oct;80(4):610-20. [2]. Duggan ST, McKeage K. Bazedoxifene: a review of its use in the treatment of postmenopausal osteoporosis. Drugs. 2011 Nov 12;71(16):2193-212. [3]. Lello S, Brandi ML, Minisola G et al. Bazedoxifene: literature data and clinical evidence. Clin Cases Miner Bone Metab. 2011 Sep;8(3):29-32. [4]. Komm BS, Chines AA. Bazedoxifene: the evolving role of third-generation selective estrogen-receptor modulators in the management of postmenopausal osteoporosis. Ther Adv Musculoskelet Dis. 2012 Feb;4(1):21-34.

Description

Bazedoxifene is a selective estrogen receptor modulator (SERM) currently in development for osteoporosis prevention and treatment.IC50 value:Target: estrogen receptor modulatorPreclinical and clinical studies with bazedoxifene demonstrate more tissue selectivity than other SERMs. In particular, bazedoxifene has minimal if any agonist activity in the uterus and is able to antagonize effects of estrogen on the uterus. Animal studies and early clinical studies suggest effects in the bone similar to other SERMs with prevention of postmenopausal bone loss.

Related Catalog

Signaling Pathways >>Others >>Estrogen Receptor/ERRResearch Areas >>Cancer

References

[1]. Lewis-Wambi JS, et al. The selective estrogen receptor modulator bazedoxifene inhibits hormone-independent breast cancer cell growth and down-regulates estrogen receptor α and cyclin D1. Mol Pharmacol. 2011 Oct;80(4):610-20.

[2]. Duggan ST, McKeage K. Bazedoxifene: a review of its use in the treatment of postmenopausal osteoporosis. Drugs. 2011 Nov 12;71(16):2193-212.

[3]. Lello S, Brandi ML, Minisola G et al. Bazedoxifene: literature data and clinical evidence. Clin Cases Miner Bone Metab. 2011 Sep;8(3):29-32.

[4]. Komm BS, Chines AA. Bazedoxifene: the evolving role of third-generation selective estrogen-receptor modulators in the management of postmenopausal osteoporosis. Ther Adv Musculoskelet Dis. 2012 Feb;4(1):21-34.

Chemical & Physical Properties

Density	1.2±0.1 g/cm3
Boiling Point	694.4±55.0 °C at 760 mmHg
Molecular Formula	C₃₀H₃₄N₂O₃
Molecular Weight	470.603
Flash Point	373.8±31.5 °C
Exact Mass	470.256958
PSA	57.86000
LogP	6.59
Vapour Pressure	0.0±2.3 mmHg at 25°C
Index of Refraction	1.622
InChIKey	UCJGJABZCDBEDK-UHFFFAOYSA-N
SMILES	Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CCCCCC3)cc2)c2ccc(O)cc12
Storage condition	2-8℃

Synonyms

TSE-424

Bazedoxifene

1H-Indol-5-ol, 1-[[4-[2-(hexahydro-1H-azepin-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methyl-

1-[[4-[2-(azepan-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methyl-indol-5-ol

1-{4-[2-(Azepan-1-yl)ethoxy]benzyl}-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol

Bazedoxifeno

1-{4-[2-(1-Azepanyl)ethoxy]benzyl}-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol

1H-Indol-5-ol, 1-((4-(2-(hexahydro-1H-azepin-1-yl)ethoxy)phenyl)methyl)-2-(4-hydroxyphenyl)-3-methyl-

Conbriza

Recommended......