CAS 40596-69-8|Methoprene
Introduction：Basic information about CAS 40596-69-8|Methoprene, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Methoprene | ||
|---|---|---|---|
| CAS Number | 40596-69-8 | Molecular Weight | 310.471 |
| Density | 0.9±0.1 g/cm3 | Boiling Point | 385.7±25.0 °C at 760 mmHg |
| Molecular Formula | C19H34O3 | Melting Point | 164ºC |
| MSDS | ChineseUSA | Flash Point | 162.4±17.8 °C |
| Symbol | GHS07, GHS09 | Signal Word | Warning |
Names
| Name | methoprene |
|---|---|
| Synonym | More Synonyms |
Methoprene BiologicalActivity
| Description | Methoprene is a juvenile hormone (JH) analog, does not kill insects, acts as an insect growth regulator, interferes with an insect's lifecycle and prevents it from reaching maturity or reproducing, is a biological pesticide. |
|---|---|
| Related Catalog | Signaling Pathways >>Anti-infection >>ParasiteResearch Areas >>Infection |
Chemical & Physical Properties
| Density | 0.9±0.1 g/cm3 |
|---|---|
| Boiling Point | 385.7±25.0 °C at 760 mmHg |
| Melting Point | 164ºC |
| Molecular Formula | C19H34O3 |
| Molecular Weight | 310.471 |
| Flash Point | 162.4±17.8 °C |
| Exact Mass | 310.250793 |
| PSA | 35.53000 |
| LogP | 5.63 |
| Vapour Pressure | 0.0±0.9 mmHg at 25°C |
| Index of Refraction | 1.462 |
| InChIKey | NFGXHKASABOEEW-LDRANXPESA-N |
| SMILES | COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C |
| Storage condition | 0-6°C |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 25 gm/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Behavioral - somnolence (general depressed activity) Nutritional and Gross Metabolic - body temperature decrease
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >210 gm/m3
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 5 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 3038 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 3 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- >210 gm/m3
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 84 mg/kg/3W-I
- TOXIC EFFECTS :
- Endocrine - changes in adrenal weight Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- Specific locus test
MUTATION DATA - TYPE OF TEST :
- Mutation test systems - not otherwise specified
- TEST SYSTEM :
- Insect - not otherwise specified Ovary
- DOSE/DURATION :
- 100 umol/L
- REFERENCE :
- ABCHA6 Agricultural and Biological Chemistry. (Maruzen Co. Ltd., POB 5050, Tokyo International, Tokyo 100-31, Japan) V.25- 1961- Volume(issue)/page/year: 43,1285,1979 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989
- TYPE OF TEST :
- Mutation test systems - not otherwise specified
- TEST SYSTEM :
- Insect - not otherwise specified Ovary
- DOSE/DURATION :
- 100 umol/L
- REFERENCE :
- ABCHA6 Agricultural and Biological Chemistry. (Maruzen Co. Ltd., POB 5050, Tokyo International, Tokyo 100-31, Japan) V.25- 1961- Volume(issue)/page/year: 43,1285,1979 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989
Safety Information
| Symbol | GHS07, GHS09 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335-H411 |
| Precautionary Statements | P261-P273-P305 + P351 + P338 |
| Personal Protective Equipment | Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter |
| Hazard Codes | Xi: Irritant;N: Dangerous for the environment; |
| Risk Phrases | R36/37/38 |
| Safety Phrases | 26-36-60-61 |
| RIDADR | UN3082 9/PG 3 |
| RTECS | JR1685000 |
| HS Code | 2918990090 |
Customs
| HS Code | 2918990090 |
|---|---|
| Summary | 2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
Articles44
More Articles| Methoprene-tolerant (Met) knockdown in the adult female cockroach, Diploptera punctata completely inhibits ovarian development. PLoS ONE 9(9) , e106737, (2014) Independent of the design of the life cycle of any insect, their growth and reproduction are highly choreographed through the action of two versatile hormones: ecdysteroids and juvenile hormones (JH).... | |
| Methyl farnesoate plays a dual role in regulating Drosophila metamorphosis. PLoS Genet. 11(3) , e1005038, (2015) Corpus allatum (CA) ablation results in juvenile hormone (JH) deficiency and pupal lethality in Drosophila. The fly CA produces and releases three sesquiterpenoid hormones: JH III bisepoxide (JHB3), J... | |
| Ligand-binding properties of a juvenile hormone receptor, Methoprene-tolerant. Proc. Natl. Acad. Sci. U. S. A. 108(52) , 21128-33, (2011) Juvenile hormone (JH) is a sesquiterpenoid of vital importance for insect development, yet the molecular basis of JH signaling remains obscure, mainly because a bona fide JH receptor has not been iden... |
Synonyms
| Isopropyl (2E,4E)-11-methoxy-3,7,11-trimethyldodeca-2,4-dienoate |
| Methoprene |
| EINECS 254-993-2 |
| MFCD00072475 |
| Isopropyl (2E,4E)-11-Methoxy-3,7,11-trimethyldodeca-trans-2,trans-4-dienoate |
| UNII:8B830OJ2UX |
| isopropyl (E,E)-(RS)-11-methoxy-3,7,11-trimethyldodeca-2,4-dienoate |
| 1-methylethyl (2E,4E)-11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate |
| 2,4-Dodecadienoic acid, 11-methoxy-3,7,11-trimethyl-, 1-methylethyl ester, (2E,4E)- |
| 1-methylene-indan-4-ol |
| 1-Methylethyl (2E,4E)-11-methoxy-3,7,11-trimethyldodeca-2,4-dienoate |
| isopropyl 11-methoxy-3,7,11-trimethyldodeca-2E,4E-1-dienoate |
| rac-propan-2-yl (2E,4E,7R)-11-methoxy-3,7,11-trimethyldodeca-2,4-dienoate |
| juvemon |
| Isopropyl (2E,4E)-11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate |
