CAS 114482-86-9|Oroxin B

Introduction：Basic information about CAS 114482-86-9|Oroxin B, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Oroxin B BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	Oroxin B
CAS Number	114482-86-9	Molecular Weight	594.518
Density	1.8±0.1 g/cm3	Boiling Point	957.5±65.0 °C at 760 mmHg
Molecular Formula	C₂₇H₃₀O₁₅	Melting Point	/
MSDS	ChineseUSA	Flash Point	318.1±27.8 °C

Names

Name	5,6-Dihydroxy-4-oxo-2-phenyl-4H-chromen-7-yl 6-O-β-D-glucopyranos yl-β-D-glucopyranoside
Synonym	More Synonyms

Oroxin B BiologicalActivity

Description	Oroxin B (OB) is a flavonoid isolated from traditional Chinese herbal medicine Oroxylum indicum (L.) Vent. Oroxin B (OB) possesses obvious inhibitory effect and induces early apoptosis rather than late apoptosis on liver cancer cells through upregulation of PTEN, down regulation of COX-2, VEGF, PI3K, and p-AKT[1].Oroxin B (OB) selectively induces tumor-suppressive ER stress in malignant lymphoma cells[2].
Related Catalog	Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>CancerSignaling Pathways >>PI3K/Akt/mTOR >>PI3KSignaling Pathways >>PI3K/Akt/mTOR >>PTEN
References	[1]. Li NN, et al. Evidence for the Involvement of COX-2/VEGF and PTEN/Pl3K/AKT Pathway the Mechanism of Oroxin B Treated Liver Cancer. Pharmacogn Mag. 2018 Apr-Jun;14(54):207-213. [2]. Yang P, et al. Oroxin B selectively induces tumor-suppressive ER stress and concurrently inhibits tumor-adaptive ER stress in B-lymphoma cells for effective anti-lymphoma therapy. Toxicol Appl Pharmacol. 2015 Oct 15;288(2):269-79.

Description

Oroxin B (OB) is a flavonoid isolated from traditional Chinese herbal medicine Oroxylum indicum (L.) Vent. Oroxin B (OB) possesses obvious inhibitory effect and induces early apoptosis rather than late apoptosis on liver cancer cells through upregulation of PTEN, down regulation of COX-2, VEGF, PI3K, and p-AKT[1].Oroxin B (OB) selectively induces tumor-suppressive ER stress in malignant lymphoma cells[2].

Related Catalog

Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>CancerSignaling Pathways >>PI3K/Akt/mTOR >>PI3KSignaling Pathways >>PI3K/Akt/mTOR >>PTEN

References

[1]. Li NN, et al. Evidence for the Involvement of COX-2/VEGF and PTEN/Pl3K/AKT Pathway the Mechanism of Oroxin B Treated Liver Cancer. Pharmacogn Mag. 2018 Apr-Jun;14(54):207-213.

[2]. Yang P, et al. Oroxin B selectively induces tumor-suppressive ER stress and concurrently inhibits tumor-adaptive ER stress in B-lymphoma cells for effective anti-lymphoma therapy. Toxicol Appl Pharmacol. 2015 Oct 15;288(2):269-79.

Chemical & Physical Properties

Density	1.8±0.1 g/cm3
Boiling Point	957.5±65.0 °C at 760 mmHg
Molecular Formula	C₂₇H₃₀O₁₅
Molecular Weight	594.518
Flash Point	318.1±27.8 °C
Exact Mass	594.158447
PSA	249.20000
LogP	-0.57
Vapour Pressure	0.0±0.3 mmHg at 25°C
Index of Refraction	1.745
InChIKey	HAYLVXFWJCKKDW-IJTBWITGSA-N
SMILES	O=c1cc(-c2ccccc2)oc2cc(OC3OC(COC4OC(CO)C(O)C(O)C4O)C(O)C(O)C3O)c(O)c(O)c12
Storage condition	-20 °C

Safety Information

Safety Phrases	24/25
RIDADR	NONH for all modes of transport
HS Code	29389090

Synonyms

5,6-Dihydroxy-4-oxo-2-phenyl-4H-chromen-7-yl 6-O-β-D-glucopyranosyl-β-D-glucopyranoside

Baicalin-7-diglucoside

Oroxin B

4H-1-Benzopyran-4-one, 7-[(6-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy]-5,6-dihydroxy-2-phenyl-

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