CAS 207671-44-1|Quinine hemisulfate hydrate
| Common Name | Quinine hemisulfate hydrate | ||
|---|---|---|---|
| CAS Number | 207671-44-1 | Molecular Weight | 782.94300 |
| Density | / | Boiling Point | / |
| Molecular Formula | C20H24N2O2.1/2H2O4S.H2O | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | / |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | Hydrogen sulfate-(8α,9R)-6'-methoxycinchonan-9-ol hydrate (2:1: 2:2) |
|---|---|
| Synonym | More Synonyms |
Quinine hemisulfate hydrate BiologicalActivity
| Description | Quinine hemisulfate hydrate is an alkaloid derived from the bark of the cinchona tree, acts as an anti-malaria agent. Quinine hemisulfate hydrate is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100 mV with an IC50 of 169 μM[1][2]. |
|---|---|
| Related Catalog | Research Areas >>InfectionSignaling Pathways >>Membrane Transporter/Ion Channel >>Potassium Channel |
| Target | IC50: Parasite[1], 169 μM (mSlo3)[2] |
| References | [1]. Jane Achan , et al. Quinine, an Old Anti-Malarial Drug in a Modern World: Role in the Treatment of Malaria. Malar J. 2011 May 24;10:144. [2]. Wrighton DC, et al. Mechanism of inhibition of mouse Slo3 (KCa 5.1) potassium channels by quinine, quinidine and barium. Br J Pharmacol. 2015 Sep;172(17):4355-63. |
Chemical & Physical Properties
| Molecular Formula | C20H24N2O2.1/2H2O4S.H2O |
|---|---|
| Molecular Weight | 782.94300 |
| Exact Mass | 782.35600 |
| PSA | 192.62000 |
| LogP | 6.52160 |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi |
| RIDADR | NONH for all modes of transport |
Articles27
More Articles| Interaction of quinine sulfate with anionic micelles of sodium dodecylsulfate: A time-resolved fluorescence spectroscopy at different pH. Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 148 , 49-59, (2015) Photophysical behavior and rotational relaxation dynamics of quinine sulfate (QS) in anionic surfactant, sodium dodecylsulfate (SDS) at different pH have been studied using steady state and time resol... | |
| The uptake of trehalose glycolipids by macrophages is independent of Mincle. ChemBioChem. 16(4) , 683-93, (2015) Trehalose glycolipids play an important role in the pathogenesis of Mycobacterium tuberculosis and are used as adjuvants for vaccines; however, much still remains unanswered about the mechanisms throu... | |
| In vivo antimalarial activity and mechanisms of action of 4-nerolidylcatechol derivatives. Antimicrob. Agents Chemother. 59 , 3271-80, (2015) 4-Nerolidylcatechol (1) is an abundant antiplasmodial metabolite that is isolated from Piper peltatum roots. O-Acylation or O-alkylation of compound 1 provides derivatives exhibiting improved stabilit... |
Synonyms
| Quinine hemisulfate |
| Quinine sulfate |
