Introduction：Basic information about CAS 548-76-5|Irigenin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Irigenin |
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| CAS Number | 548-76-5 | Molecular Weight | 360.31500 |
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| Density | 1.461g/cm3 | Boiling Point | 646.1ºC at 760mmHg |
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| Molecular Formula | C18H16O8 | Melting Point | 189-192ºC |
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| MSDS | / | Flash Point | 237.7ºC |
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Names
| Name | irigenin |
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| Synonym | More Synonyms |
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Irigenin BiologicalActivity
| Description | Irigenin is a is a lead compound, and mediates its anti-metastatic effect by specifically and selectively blocking α9β1 and α4β1 integrins binding sites on C-C loop of Extra Domain A (EDA). Irigenin shows anti-cancer properties. It sensitizes TRAIL-induced apoptosis via enhancing pro-apoptotic molecules in gastric cancer cells[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Cytoskeleton >>Integrin |
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| In Vitro | Irigenin specifically targets α9β1 and α4β1 integrin binding sites on Extra Domain A (EDA) comprising LEU46, PHE47, PRO48, GLU58, LEU59 and GLN60 in its C-C loop. Irigenin binds to the C-C loop of EDA, thereby blocking its interaction with integrins on the cell surface and thus abrogating subsequent Epithelial-Mesenchymal transition[1]. |
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| References | [1]. Amin A, et al. Irigenin, a novel lead from Western Himalayan chemiome inhibits Fibronectin-Extra Domain A induced metastasis in Lung cancer cells. Sci Rep. 2016 Nov 16;6:37151. [2]. Xu Y, et al. Irigenin sensitizes TRAIL-induced apoptosis via enhancing pro-apoptotic molecules in gastric cancer cells. Biochem Biophys Res Commun. 2018 Feb 12;496(3):998-1005. |
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Chemical & Physical Properties
| Density | 1.461g/cm3 |
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| Boiling Point | 646.1ºC at 760mmHg |
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| Melting Point | 189-192ºC |
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| Molecular Formula | C18H16O8 |
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| Molecular Weight | 360.31500 |
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| Flash Point | 237.7ºC |
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| Exact Mass | 360.08500 |
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| PSA | 118.59000 |
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| LogP | 2.60260 |
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| Index of Refraction | 1.649 |
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| InChIKey | TUGWPJJTQNLKCL-UHFFFAOYSA-N |
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| SMILES | COc1cc(-c2coc3cc(O)c(OC)c(O)c3c2=O)cc(O)c1OC |
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| Storage condition | 2-8C |
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Safety Information
Customs
| HS Code | 2914509090 |
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| Summary | HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0% |
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Synonyms
| 5,7-dihydroxy-3-(3-hydroxy-4,5-dimethoxyphenyl)-6-methoxychromen-4-one |
| 7,5,3'-Trihydroxy-6,4',5'-trimethoxyisoflavon |
| 5,7,3'-trihydroxy-6,4',5'-trimethoxyisoflavone |
| Irigenin |
| EINECS 208-958-3 |
