Introduction：Basic information about CAS 115103-15-6|tribendimidine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | tribendimidine |
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| CAS Number | 115103-15-6 | Molecular Weight | 452.59400 |
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| Density | 1.04g/cm3 | Boiling Point | 618.2ºC at 760mmHg |
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| Molecular Formula | C28H32N6 | Melting Point | / |
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| MSDS | / | Flash Point | 327.7ºC |
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Names
| Name | N'-[4-[[4-[[4-[1-(dimethylamino)ethylideneamino]phenyl]iminomethyl]phenyl]methylideneamino]phenyl]-N,N-dimethylethanimidamide |
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| Synonym | More Synonyms |
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tribendimidine BiologicalActivity
| Description | Tribendimidine is an orally active, broad-spectrum anthelmintic agent, with particularly high activity against A. lumbricoides and N. americanus. Tribendimidine is also an L-type nicotinic acetylcholine receptor (nAChR) agonist[1][2][3]. |
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| Related Catalog | Research Areas >>InfectionSignaling Pathways >>Membrane Transporter/Ion Channel >>nAChRSignaling Pathways >>Neuronal Signaling >>nAChR |
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| In Vitro | Tribendimidine (100 μg/mL, 24 h) shows intoxication of C. elegans[3]. Tribendimidine (0-100 μg/mL, 6 days) shows toxicity with an LC50 value (concentration at which half the animals are dead) of 54.4 μg/mL[3]. Tribendimidine (0-200 μg/mL, 64 h)-induced sterility is resisted by trb mutant hermaphrodites, and Levamisole-resistant mutants are resistant to Tribendimidine. [3]. |
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| In Vivo | Tribendimidine (75 and 150 mg/kg; p.o.; once) shows inhibition activity against C. sinensis in rats, and shows inhibition against O. viverrini at 400 mg/kg in hamsters[2]. Animal Model: C. sinensis infected Female Wistar rats[2] Dosage: 75 mg/kg and 150 mg/kg Administration: Oral administration, once Result: A 99.1% worm burden reduction was achieved at 150 mg/kg, and the worm burden reduction was still significant (68.9%) at 75 mg/kg. |
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| References | [1]. Xiao SH, et al. Tribendimidine: a promising, safe and broad-spectrum anthelmintic agent from China. Acta Trop. 2005 Apr;94(1):1-14. [2]. Keiser J, et al. Evaluation of the in vivo activity of tribendimidine against Schistosoma mansoni, Fasciola hepatica, Clonorchis sinensis, and Opisthorchis viverrini. Antimicrob Agents Chemother. 2007 Mar;51(3):1096-8. [3]. Hu Y, et al. The new anthelmintic tribendimidine is an L-type (levamisole and pyrantel) nicotinic acetylcholine receptor agonist. PLoS Negl Trop Dis. 2009 Aug 11;3(8):e499. |
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Chemical & Physical Properties
| Density | 1.04g/cm3 |
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| Boiling Point | 618.2ºC at 760mmHg |
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| Molecular Formula | C28H32N6 |
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| Molecular Weight | 452.59400 |
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| Flash Point | 327.7ºC |
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| Exact Mass | 452.26900 |
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| PSA | 55.92000 |
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| LogP | 6.41080 |
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| Vapour Pressure | 3.26E-15mmHg at 25°C |
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| Index of Refraction | 1.575 |
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| InChIKey | XOIOGKHKNQYULW-UHFFFAOYSA-N |
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| SMILES | CC(=Nc1ccc(N=Cc2ccc(C=Nc3ccc(N=C(C)N(C)C)cc3)cc2)cc1)N(C)C |
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| Storage condition | 2-8°C |
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Synonyms
| Tribendimidine |
| Tribendimidin |
