Introduction：Basic information about CAS 1219177-18-0|Thalidomide D4, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Thalidomide D4 |
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| CAS Number | 1219177-18-0 | Molecular Weight | 262.25400 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C13H6D4N2O4 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | 4,5,6,7-tetradeuterio-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione |
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| Synonym | More Synonyms |
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Thalidomide D4 BiologicalActivity
| Description | Thalidomide D4 is a deuterium labeled Thalidomide. Thalidomide is initially promoted as a sedative, inhibits cereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1, with a Kd of ~250 nM, and has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties[1][2]. |
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| Related Catalog | Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>CancerSignaling Pathways >>Autophagy >>AutophagyResearch Areas >>Inflammation/ImmunologySignaling Pathways >>PROTAC >>Ligand for E3 Ligase |
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| Target | Kd: ~250 nM (CRL4CRBN)[1] |
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| References | [1]. Fischer ES, et al. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature. 2014 Aug 7;512(7512):49-53. [2]. Sun X, et al. Synergistic Inhibition of Thalidomide and Icotinib on Human Non-Small Cell Lung Carcinomas Through ERK and AKT Signaling. Med Sci Monit. 2018 May 15;24:3193-3203. |
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Chemical & Physical Properties
| Molecular Formula | C13H6D4N2O4 |
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| Molecular Weight | 262.25400 |
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| Exact Mass | 262.08900 |
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| PSA | 87.04000 |
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| LogP | 0.30160 |
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| InChIKey | UEJJHQNACJXSKW-RHQRLBAQSA-N |
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| SMILES | O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1 |
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Synonyms
| |A-Phthalimidoglutarimide-d4 |
| Myrin-d4 |
| 3-Phthalimidoglutarimide-d4 |
| Celgene-d4 |
| Contergan-d4 |
| Thalidomide-d4 |
| Distaval-d4 |
| Kevadon-d4 |
