Introduction：Basic information about CAS 144506-14-9|Licochalcone C, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Licochalcone C |
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| CAS Number | 144506-14-9 | Molecular Weight | 338.397 |
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| Density | 1.2±0.1 g/cm3 | Boiling Point | 536.1±50.0 °C at 760 mmHg |
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| Molecular Formula | C21H22O4 | Melting Point | / |
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| MSDS | / | Flash Point | 188.4±23.6 °C |
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Names
| Name | (E)-3-[4-hydroxy-2-methoxy-3-(3-methylbut-2-enyl)phenyl]-1-(4-hydroxyphenyl)prop-2-en-1-one |
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| Synonym | More Synonyms |
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Licochalcone C BiologicalActivity
| Description | Licochalcone C could inhibit α-glucosidase, with IC50s of <100 nM and 92.43 μM for α-glucosidase and protein tyrosine phosphatase 1B (PTP1B), respectively. |
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| Related Catalog | Signaling Pathways >>Others >>OthersNatural Products >>FlavonoidsResearch Areas >>Metabolic Disease |
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| Target | IC50: <100 nM (α-glucosidase), 92.43 μM (PTP1B)[1]. |
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| In Vitro | Licochalcone C could inhibit α- glucosidase, with IC50s of <100 nM and 92.43 μM for α- glucosidase and PTP1B, respectively[1]. It is also indicated that Licochalcone C induces T24 cell apoptosis in a concentration‑dependent manner. Licochalcone C treatment reduces the levels of the anti‑apoptotic mRNAs (Bcl-2, Bcl-w and Bcl-XL) and increases expression of the pro-apoptotic mRNAs (Bax and Bim). The Bcl-2 family inhibitor (ABT-737) reduces apoptosis induced by licochalcone C in T24 cells[2]. |
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| References | [1]. Zhenghong Guo, et al. Chemical profile and inhibition of α-glycosidase and protein tyrosine phosphatase 1B (PTP1B) activities by flavonoids from licorice (Glycyrrhiza uralensis Fisch). journal of functional foods 14 ( 2015 ) 324-336. [2]. PENGLONG WANG, et al. Licochalcone C induces apoptosis via B-cell lymphoma 2 family proteins in T24 cells. Mol Med Rep. 2015 Nov;12(5):7623-8. |
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Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
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| Boiling Point | 536.1±50.0 °C at 760 mmHg |
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| Molecular Formula | C21H22O4 |
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| Molecular Weight | 338.397 |
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| Flash Point | 188.4±23.6 °C |
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| Exact Mass | 338.151794 |
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| PSA | 66.76000 |
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| LogP | 5.33 |
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| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
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| Index of Refraction | 1.622 |
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| InChIKey | WBDNTJSRHDSPSR-KPKJPENVSA-N |
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| SMILES | COc1c(C=CC(=O)c2ccc(O)cc2)ccc(O)c1CC=C(C)C |
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| Storage condition | 2-8C |
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Synonyms
| 2-Propen-1-one, 3-[4-hydroxy-2-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-1-(4-hydroxyphenyl)-, (2E)- |
| (2E)-3-[4-hydroxy-2-methoxy-3-(3-methylbut-2-en-1-yl)phenyl]-1-(4-hydroxyphenyl)prop-2-en-1-one |
| Y0122 |
| (2E)-3-[4-Hydroxy-2-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-1-(4-hydroxyphenyl)-2-propen-1-one |
| Licochalcone C |
| UNII-P1H7W3812O |
