CAS 143-24-8|Me-PEG4-Me

Introduction：Basic information about CAS 143-24-8|Me-PEG4-Me, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Me-PEG4-Me BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Customs
7. Articles29
8. Synonyms

Common Name	Me-PEG4-Me
CAS Number	143-24-8	Molecular Weight	222.279
Density	1.0±0.1 g/cm3	Boiling Point	275.3±0.0 °C at 760 mmHg
Molecular Formula	C₁₀H₂₂O₅	Melting Point	−30 °C(lit.)
MSDS	ChineseUSA	Flash Point	140.6±0.0 °C
Symbol	GHS08	Signal Word	Danger

Names

Name	tetraglyme
Synonym	More Synonyms

Me-PEG4-Me BiologicalActivity

Description	Me-PEG4-Me is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >>CancerSignaling Pathways >>PROTAC >>PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

Density	1.0±0.1 g/cm3
Boiling Point	275.3±0.0 °C at 760 mmHg
Melting Point	−30 °C(lit.)
Molecular Formula	C₁₀H₂₂O₅
Molecular Weight	222.279
Flash Point	140.6±0.0 °C
Exact Mass	222.146729
PSA	46.15000
LogP	-1.51
Vapour density	7.7 (vs air)
Vapour Pressure	0.0±0.5 mmHg at 25°C
Index of Refraction	1.421
InChIKey	ZUHZGEOKBKGPSW-UHFFFAOYSA-N
SMILES	COCCOCCOCCOCCOC

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SB0400000

CHEMICAL NAME :: 2,5,8,11,14-Pentaoxapentadecane

CAS REGISTRY NUMBER :: 143-24-8

BEILSTEIN REFERENCE NO. :: 1760005

LAST UPDATED :: 199710

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C10-H22-O5

MOLECULAR WEIGHT :: 222.32

WISWESSER LINE NOTATION :: 1O2O2O2O2O1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918- Volume(issue)/page/year: 29,1363,1946 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5140 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Gastrointestinal - other changes Kidney, Ureter, Bladder - other changes

REFERENCE :: JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 23,259,1941 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 1000 ppm/7H

SEX/DURATION :: male 5 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females) Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 70,303,1983

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 1000 ppm/7H

SEX/DURATION :: male 5 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 70,303,1983

Safety Information

Symbol	GHS08
Signal Word	Danger
Hazard Statements	H360Df
Precautionary Statements	P201-P308 + P313
Personal Protective Equipment	Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	Xi:Irritant;
Risk Phrases	R19;R43
Safety Phrases	S36-S24
RIDADR	NONH for all modes of transport
WGK Germany	1
RTECS	SB0400000
HS Code	2942000000

Customs

HS Code	2901100000
Summary	2901100000 saturated acyclic hydrocarbons。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:2.0%。General tariff:30.0%

Articles29

Radical Cationic Pathway for the Decay of Ionized Glyme Molecules in Liquid Solution.

J. Phys. Chem. B 119 , 14472-8, (2015)

Chemical stability of primary radical cations (RCs) generated in irradiated matter determines substantially the radiation resistance of organic materials. Transformations of the RCs of the glyme molec...

Development of bipolar all-solid-state lithium battery based on quasi-solid-state electrolyte containing tetraglyme-LiTFSA equimolar complex.

Sci. Rep. 5 , 8869, (2015)

The development of high energy-density lithium-ion secondary batteries as storage batteries in vehicles is attracting increasing attention. In this study, high-voltage bipolar stacked batteries with a...

Mechanism and Kinetics of Li2S Precipitation in Lithium-Sulfur Batteries.

Adv. Mater. 27 , 5203-9, (2015)

The kinetics of Li2 S electrodeposition onto carbon in lithium-sulfur batteries are characterized. Electrodeposition is found to be dominated by a 2D nucleation and growth process with rate constants ...

Synonyms

tetraglyme

Dimethyltetraglycol

Bis[2-(2-methoxyethoxy)ethyl] ether

MFCD00008505

2,5,8,11,14-Pentaoxapentadecane

EINECS 205-594-7

1-methoxy-2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethane

2,5,8,11,14-Pentaoxapentadecane (Bis[2-(2-methoxyethoxy)ethyl] ether

Dimethoxytetraethylene glycol

Tetraethylene glycol dimethyl ether

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