Introduction：Basic information about CAS 91-80-5|Methapyrilene, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Methapyrilene |
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| CAS Number | 91-80-5 | Molecular Weight | 261.38600 |
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| Density | / | Boiling Point | 173 - 175ºC at 3 mm Hg |
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| Molecular Formula | C14H19N3S | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | methapyrilene |
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| Synonym | More Synonyms |
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Methapyrilene BiologicalActivity
| Description | Methapyrilene is a histamine antagonist, a pyridine chemical with anticholinergic activity. Methapyrilene can cause target organ-specific epigenetic alterations, such as a decrease in DNA methylation levels. Methapyrilene induces hepatocellular carcinoma in rats[1][2]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Neuronal Signaling >>mAChRSignaling Pathways >>Immunology/Inflammation >>Histamine ReceptorSignaling Pathways >>GPCR/G Protein >>mAChRResearch Areas >>Neurological DiseaseSignaling Pathways >>GPCR/G Protein >>Histamine Receptor |
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| In Vitro | Methapyrilene (650 μM, 72 h) decreases the transcriptional level of transferrin and is accompanied by a decrease in transferrin protein levels in HepRG cells[1]. |
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| In Vivo | Methapyrilene (gavage with water (vehicle), 50 or 150 mg/kg, daily, 3 days) can induce hepatotoxicity and lead to periportal hepatic necrosis in rats[2]. Animal Model: Male Wistar derived AlpK:APfSD (Alderley Park) rats[2] Dosage: 50 mg/kg, 150 mg/kg Administration: Gavage with water (vehicle), daily, 3 days Result: Showed mild to moderate periportal hepatocyte degeneration and necrosis as well as acute inflammatory cells were observed in the filtering periportal vein at a dose concentration of 150 mg/kg. Decreased levels of both glucose and glycogen in the liver. Showed higher levels of succinic acid and dimethylglycine of urine obtained from the low dose group of 50 mg/kg. |
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Chemical & Physical Properties
| Boiling Point | 173 - 175ºC at 3 mm Hg |
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| Molecular Formula | C14H19N3S |
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| Molecular Weight | 261.38600 |
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| Exact Mass | 261.13000 |
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| PSA | 47.61000 |
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| LogP | 2.71130 |
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| InChIKey | HNJJXZKZRAWDPF-UHFFFAOYSA-N |
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| SMILES | CN(C)CCN(Cc1cccs1)c1ccccn1 |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- UT1400000
- CHEMICAL NAME :
- Pyridine, 2-((2-(dimethylamino)ethyl)-2-thenylamino)-
- CAS REGISTRY NUMBER :
- 91-80-5
- BEILSTEIN REFERENCE NO. :
- 0220729
- LAST UPDATED :
- 199706
- DATA ITEMS CITED :
- 9
- MOLECULAR FORMULA :
- C14-H19-N3-S
- MOLECULAR WEIGHT :
- 261.42
- WISWESSER LINE NOTATION :
- T6NJ BN2N1&1&1- BT5SJ
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 150 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Behavioral - aggression
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 182 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 77 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 20 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 375 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold
MUTATION DATA - TYPE OF TEST :
- Mutation in mammalian somatic cells
- TEST SYSTEM :
- Rodent - mouse Lymphocyte
- DOSE/DURATION :
- 100 mg/L
- REFERENCE :
- ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 5,420,1983
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Safety Information
| RIDADR | UN 1851 |
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| Packaging Group | III |
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| Hazard Class | 6.1(b) |
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Synonyms
| Restryl |
| Thenylpyramine |
| N,N-dimethyl-N'-pyridin-2-yl-N'-(thiophen-2-ylmethyl)ethane-1,2-diamine |
| Paradormalene |
| Methapyrilen |
| Semikon |
| Pyrinistol |
| Thionylan |
| Pyrinistab |
| Thenylene |
| metapyrilene |
| Tenalin |
