CAS 57078-98-5|4-(2,5-dioxo-2H-pyrrol-1(5H)-yl)butanoic acid

Introduction：Basic information about CAS 57078-98-5|4-(2,5-dioxo-2H-pyrrol-1(5H)-yl)butanoic acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	4-(2,5-dioxo-2H-pyrrol-1(5H)-yl)butanoic acid
CAS Number	57078-98-5	Molecular Weight	183.161
Density	1.4±0.1 g/cm3	Boiling Point	400.1±28.0 °C at 760 mmHg
Molecular Formula	C₈H₉NO₄	Melting Point	95-98ºC
MSDS	/	Flash Point	195.8±24.0 °C

Names

Name	4-Maleimidobutyric Acid
Synonym	More Synonyms

BiologicalActivity

Description	4-Maleimidobutyric acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >>CancerSignaling Pathways >>PROTAC >>PROTAC Linker
Target	Alkyl-Chain
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

Density	1.4±0.1 g/cm3
Boiling Point	400.1±28.0 °C at 760 mmHg
Melting Point	95-98ºC
Molecular Formula	C₈H₉NO₄
Molecular Weight	183.161
Flash Point	195.8±24.0 °C
Exact Mass	183.053162
PSA	74.68000
LogP	0.40
Vapour Pressure	0.0±2.0 mmHg at 25°C
Index of Refraction	1.553
InChIKey	NCPQROHLJFARLL-UHFFFAOYSA-N
SMILES	O=C(O)CCCN1C(=O)C=CC1=O
Storage condition	2-8°C

Safety Information

Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	26-36
WGK Germany	3

Synonyms

1H-Pyrrole-1-butanoic acid, 2,5-dihydro-2,5-dioxo-

4-(2,5-dioxopyrrol-1-yl)butanoic acid

4-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)butanoic acid

MFCD00043139

4-(2,5-Dioxo-2,5-dihydro-pyrrol-1-yl)-butyric acid

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