CAS 846549-37-9|2-((Azido-PEG8-carbamoyl)methoxy)acetic acid

Introduction：Basic information about CAS 846549-37-9|2-((Azido-PEG8-carbamoyl)methoxy)acetic acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common Name2-((Azido-PEG8-carbamoyl)methoxy)acetic acid
CAS Number846549-37-9Molecular Weight554.58800
Density/Boiling Point/
Molecular FormulaC22H42N4O12Melting Point/
MSDSChineseUSAFlash Point/
Symbol
GHS07		Signal WordWarning

Names

Name2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethylamino]-2-oxoethoxy]acetic acid
SynonymMore Synonyms

BiologicalActivity

Description2-((Azido-PEG8-carbamoyl)methoxy)acetic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related CatalogResearch Areas >>CancerSignaling Pathways >>PROTAC >>PROTAC Linker
Target

PEGs

In VitroPROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

Molecular FormulaC22H42N4O12
Molecular Weight554.58800
Exact Mass554.28000
PSA202.71000
InChIKeyWWDNBBVPYDZICO-UHFFFAOYSA-N
SMILES[N-]=[N+]=NCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)COCC(=O)O
Storage condition2-8°C

Safety Information

Symbol
GHS07
Signal WordWarning
Hazard StatementsH315-H319-H335
Precautionary StatementsP261-P305 + P351 + P338
Personal Protective EquipmentEyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard CodesXi
Risk Phrases36/37/38
Safety Phrases25
RIDADRNONH for all modes of transport

Synonyms

AmbotzPEG2015
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