CAS 912574-69-7|Selurampanel

Introduction：Basic information about CAS 912574-69-7|Selurampanel, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Selurampanel BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Selurampanel
CAS Number	912574-69-7	Molecular Weight	377.42
Density	/	Boiling Point	/
Molecular Formula	C₁₆H₁₉N₅O₄S	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	N-[6-(2-methylpyrazol-3-yl)-2,4-dioxo-7-propan-2-yl-1H-quinazolin-3-yl]methanesulfonamide
Synonym	More Synonyms

Selurampanel BiologicalActivity

Description	Selurampanel (BGG 492) is an orally active and competitive AMPA receptor antagonist with an IC50 of 190 nM. Selurampanel has reasonable blood-brain barrier penetration. Selurampanel can be used for epilepsy research[1][2].
Related Catalog	Signaling Pathways >>Neuronal Signaling >>iGluRResearch Areas >>Neurological DiseaseSignaling Pathways >>Membrane Transporter/Ion Channel >>iGluR
In Vivo	Selurampanel (Compound 1S) potently and dose-dependently antagonizes maximal electroshock seizure (MES)-induced generalized tonic-clonic seizures in mice with an ED50 value around 7 mg/kg after 1 h pre-treatment[1]. In a study with a 3 mg/kg i.v. dose, a mouse plasma half-life of 3.3 h is determined, with a moderate volume of distribution (Vdss=1.3 L/kg) and a low clearance of 5.4 mL/min▪kg[1].
References	[1]. David Orain, et al. Design and Synthesis of Selurampanel, a Novel Orally Active and Competitive AMPA Receptor Antagonist. ChemMedChem. 2017 Feb 3;12(3):197-201. [2]. Edward Faught, et al. BGG492 (selurampanel), an AMPA/kainate receptor antagonist drug for epilepsy. Expert Opin Investig Drugs. 2014 Jan;23(1):107-13.

Chemical & Physical Properties

Molecular Formula	C₁₆H₁₉N₅O₄S
Molecular Weight	377.42
Exact Mass	377.11600
PSA	127.49000
LogP	2.28290
InChIKey	MCECSFFXUPEPDB-UHFFFAOYSA-N
SMILES	CC(C)c1cc2[nH]c(=O)n(NS(C)(=O)=O)c(=O)c2cc1-c1ccnn1C

Synonyms

UNII-7WG1MR7DAR

Selurampanel

Methanesulfonamide,N-(1,4-dihydro-7-(1-methylethyl)-6-(1-methyl-1H-pyrazol-5-yl)-2,4-dioxo-3(2H)-quinazolinyl)

Selurampanel [INN]

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