Introduction：Basic information about CAS 125-10-0|d-Corlin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | d-Corlin |
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| CAS Number | 125-10-0 | Molecular Weight | 400.46 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 582.0±50.0 °C at 760 mmHg |
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| Molecular Formula | C23H28O6 | Melting Point | 240-242°C (dec.) |
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| MSDS | / | Flash Point | 200.2±23.6 °C |
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Names
| Name | cortancyl |
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| Synonym | More Synonyms |
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d-Corlin BiologicalActivity
| Description | Prednisone acetate (Prednisone 21-acetate), the acetate salt form of prednisolone, is a glucocorticoid receptor agonist with anti-inflammatory and immunomodulating properties[1]. |
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| Related Catalog | Research Areas >>Inflammation/ImmunologySignaling Pathways >>GPCR/G Protein >>Glucocorticoid Receptor |
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| Target | glucocorticoid receptor[1] |
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| References | [1]. Prednisolone acetate |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 582.0±50.0 °C at 760 mmHg |
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| Melting Point | 240-242°C (dec.) |
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| Molecular Formula | C23H28O6 |
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| Molecular Weight | 400.46 |
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| Flash Point | 200.2±23.6 °C |
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| Exact Mass | 400.188599 |
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| PSA | 97.74000 |
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| LogP | 2.66 |
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| Vapour Pressure | 0.0±3.7 mmHg at 25°C |
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| Index of Refraction | 1.580 |
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| InChIKey | MOVRKLZUVNCBIP-RFZYENFJSA-N |
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| SMILES | CC(=O)OCC(=O)C1(O)CCC2C3CCC4=CC(=O)C=CC4(C)C3C(=O)CC21C |
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| Storage condition | Refrigerator |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- TU4154085
- CHEMICAL NAME :
- Pregna-1,4-diene-3,11,20-trione, 17,21-dihydroxy-, 21-acetate
- CAS REGISTRY NUMBER :
- 125-10-0
- BEILSTEIN REFERENCE NO. :
- 2342061
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C23-H28-O6
- MOLECULAR WEIGHT :
- 400.51
- WISWESSER LINE NOTATION :
- L E5 B666 CV OV AHTTT&J A1 E1 FV1OV1 FQ
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intramuscular
- DOSE :
- 330 mg/kg
- SEX/DURATION :
- female 10 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 56,23,1980
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intramuscular
- DOSE :
- 135 mg/kg
- SEX/DURATION :
- female 10 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 56,23,1980 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3270 No. of Facilities: 18 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 1045 (estimated) No. of Female Employees: 1045 (estimated)
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Safety Information
| Hazard Codes | Xi |
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| Risk Phrases | R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . R36/37/38:Irritating to eyes, respiratory system and skin . |
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| Safety Phrases | S26-S36/37/39 |
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| HS Code | 2937210000 |
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Customs
Synonyms
| d-Corlin |
| δ-Cortelan |
| Pregna-1,4-diene-3,11,20-trione, 21- (acetyloxy)-17-hydroxy- |
| Prednisone 21-acetate |
| EINECS 204-726-0 |
| 17-Hydroxy-3,11,20-trioxopregna-1,4-dien-21-yl acetate |
| Pregna-1,4-diene-3,11,20-trione, 21-(acetyloxy)-17-hydroxy- |
| δ-Corlin |
| d-Cortelan |
| MFCD00200229 |
