CAS 113712-98-4|Tenatoprazole
| Common Name | Tenatoprazole | ||
|---|---|---|---|
| CAS Number | 113712-98-4 | Molecular Weight | 346.40 |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 591.5±60.0 °C at 760 mmHg |
| Molecular Formula | C16H18N4O3S | Melting Point | 178-180°C |
| MSDS | ChineseUSA | Flash Point | 311.5±32.9 °C |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | Tenatoprazole |
|---|---|
| Synonym | More Synonyms |
Tenatoprazole BiologicalActivity
| Description | Tenatoprazole (TU-199) is an orally active imidazopyridine-based proton pump inhibitor with a prolonged plasma half-life. Tenatoprazole inhibits hog gastric H+/K+-ATPase activity with an IC50 of 6.2 μM. Tenatoprazole blocks the interaction of ubiquitin with the ESCRT-1 factor Tsg101, inhibits production of several enveloped viruses, including EBV[1][2][3]. |
|---|---|
| Related Catalog | Research Areas >>InfectionResearch Areas >>Inflammation/ImmunologySignaling Pathways >>Membrane Transporter/Ion Channel >>Proton Pump |
| In Vitro | Tenatoprazole (TU-199) (0.1, 0.2, 0.4 mg/kg; oral; single; Heidenhain-pouch dogs) dose-dependently suppresses gastric acid secretion stimulated by histamine infusion[4]. |
| References | [1]. Thomson AB, et al. Comparison of the effects of fasting morning, fasting evening and fed bedtime administration of tenatoprazole on intragastric pH in healthy volunteers: a randomized three-way crossover study. Aliment Pharmacol Ther. 2006;23(8):1179-1187. [2]. Uchiyama K, et al. Effects of TU-199, a novel H+, K(+)-ATPase inhibitor, on gastric acid secretion and gastroduodenal ulcers in rats. Methods Find Exp Clin Pharmacol. 1999;21(2):115-122. [3]. Mannemuddhu SS, et al. Prazoles Targeting Tsg101 Inhibit Release of Epstein-Barr Virus following Reactivation from Latency. J Virol. 2021;95(13):e0246620. [4]. Uchiyama K, et al. The long-lasting effect of TU-199, a novel H+, K(+)-ATPase inhibitor, on gastric acid secretion in dogs. J Pharm Pharmacol. 1999;51(4):457-464. |
Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 591.5±60.0 °C at 760 mmHg |
| Melting Point | 178-180°C |
| Molecular Formula | C16H18N4O3S |
| Molecular Weight | 346.40 |
| Flash Point | 311.5±32.9 °C |
| Exact Mass | 346.109955 |
| PSA | 109.20000 |
| LogP | 1.36 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Index of Refraction | 1.674 |
| InChIKey | ZBFDAUIVDSSISP-UHFFFAOYSA-N |
| SMILES | COc1ccc2[nH]c(S(=O)Cc3ncc(C)c(OC)c3C)nc2n1 |
| Storage condition | −20°C |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H315-H319-H335 |
| Precautionary Statements | P301 + P312 + P330-P305 + P351 + P338 |
| Hazard Codes | Xn: Harmful; |
| Risk Phrases | R22 |
| Safety Phrases | 26-36/37 |
| RIDADR | NONH for all modes of transport |
Synonyms
| 5-Methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-imidazo[4,5-b]pyridine |
| (±)-5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]sulfinyl]-1H-imidazo[4,5-b]pyridine |
| 1H-Imidazo[4,5-b]pyridine, 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]- |
| 5-Methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-3H-imidazo[4,5-b]pyridine |
| tenatoprazole/tu-199 |
| 5-Methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-imidazo[4,5-b]pyridin |
| Tenatoprazole |
| 5-Methoxy-2-{[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl}-1H-imidazo[4,5-b]pyridine |
| tenatoprazole monosodium |
