Introduction：Basic information about CAS 113806-05-6|Olopatadine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Olopatadine |
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| CAS Number | 113806-05-6 | Molecular Weight | 337.412 |
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| Density | 1.2±0.1 g/cm3 | Boiling Point | 523.0±50.0 °C at 760 mmHg |
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| Molecular Formula | C21H23NO3 | Melting Point | / |
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| MSDS | / | Flash Point | 270.1±30.1 °C |
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Names
| Name | Olopatadine |
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| Synonym | More Synonyms |
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Olopatadine BiologicalActivity
| Description | Olopatadine is an orally active and selective histamine 1 (H1) receptor antagonist and a mast cell stabilizer. Olopatadine prevents immunologically stimulated pro-inflammatory mediator release from human conjunctival mast cells. Olopatadine can be used for researching allergic conjunctivitis[1][2]. |
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| Related Catalog | Signaling Pathways >>Immunology/Inflammation >>Histamine ReceptorResearch Areas >>Inflammation/ImmunologySignaling Pathways >>GPCR/G Protein >>Histamine Receptor |
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| Target | H1 Receptor |
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| In Vitro | Olopatadine inhibits anti-IgE antibody-mediated release of TNF-α from human conjunctival mast cells, and significantly decreases the mast cell supernatant-mediated upregulation of ICAM (intercellular adhesion molecule)-1 on human conjunctival epithelial cells in vitro[2]. |
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| References | [1]. Kam KW, et al. Topical Olopatadine in the Treatment of Allergic Conjunctivitis: A Systematic Review and Meta-analysis. Ocul Immunol Inflamm. 2017 Oct;25(5):663-677. [2]. Leonardi A, et al. Olopatadine: a drug for allergic conjunctivitis targeting the mast cell. Expert Opin Pharmacother. 2010 Apr;11(6):969-81. |
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Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
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| Boiling Point | 523.0±50.0 °C at 760 mmHg |
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| Molecular Formula | C21H23NO3 |
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| Molecular Weight | 337.412 |
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| Flash Point | 270.1±30.1 °C |
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| Exact Mass | 337.167786 |
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| PSA | 49.77000 |
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| LogP | 3.14 |
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| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
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| Index of Refraction | 1.641 |
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| InChIKey | JBIMVDZLSHOPLA-LSCVHKIXSA-N |
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| SMILES | CN(C)CCC=C1c2ccccc2COc2ccc(CC(=O)O)cc21 |
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Synonyms
| {(11E)-11-[3-(Dimethylamino)propylidene]-6,11-dihydrodibenzo[b,e]oxepin-2-yl}acetic acid |
| Dibenz[b,e]oxepin-2-acetic acid, 11-[3-(dimethylamino)propylidene]-6,11-dihydro-, (11E)- |
| MFCD00865645 |
| KW 4679 |
| Olopatatadine |
